Reactome | EML4(1-496)-ALK(1058-1620) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

EML4(1-496)-ALK(1058-1620) fusion [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9700022] EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9700022] EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:9699845] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233 [DatabaseIdentifier:9713343] COSMIC:COSF409
dbId	9699812
disease	[Disease:1247848] non-small cell lung carcinoma
displayName	EML4(1-496)-ALK(1058-1620) fusion [cytosol]
endCoordinate	496
hasModifiedResidue	[FragmentInsertionModification:9832408] Insertion of residues 1058 to 1620 at 497 from UniProt:Q9UM73 ALK
inDisease	true
literatureReference	[LiteratureReference:9648139] Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer [LiteratureReference:9701376] Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer
maxDepth	1
memberOf	[CandidateSet:R-HSA-9700080] ALK fusion proteins [cytosol] - Homo sapiens
modified	[InstanceEdit:9832410] Orlic-Milacic, Marija, 2023-03-30
name	EML4(1-496)-ALK(1058-1620) fusion Echinoderm microtubule-associated protein-like 4 EMAL4_HUMAN EXON13-EXON 20 variant 1
referenceEntity	[ReferenceGeneProduct:uniprot:Q9HC35] UniProt:Q9HC35 EML4
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9699812
startCoordinate	1
updateTrackers	[UpdateTracker:9904931] Update Tracker - [EntityWithAccessionedSequence:9699812] EML4(1-496)-ALK(1058-1620) fusion [cytosol] - v84:[modifyName] [UpdateTracker:9905870] Update Tracker - [EntityWithAccessionedSequence:9699812] EML4(1-496)-ALK(1058-1620) fusion [cytosol] - v85:[add_removeHasModifiedResidue]

Referrals

(updatedInstance)	[UpdateTracker:9904931] Update Tracker - [EntityWithAccessionedSequence:9699812] EML4(1-496)-ALK(1058-1620) fusion [cytosol] - v84:[modifyName] [UpdateTracker:9905870] Update Tracker - [EntityWithAccessionedSequence:9699812] EML4(1-496)-ALK(1058-1620) fusion [cytosol] - v85:[add_removeHasModifiedResidue]
(hasMember)	[CandidateSet:R-HSA-9700080] ALK fusion proteins [cytosol]
(hasComponent)	[Complex:R-HSA-9700022] EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol]

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