Reactome | TPM4(2-222)insV-ALK(1059-1620) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9710895] TPM4(2-221)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9710895] TPM4(2-221)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:9710843] Rothfels, Karen, 2021-01-05
crossReference	[DatabaseIdentifier:12021385] Mondo:0015798 [DatabaseIdentifier:9713346] COSMIC:COSF441
dbId	9710851
disease	[Disease:9701987] inflammatory myofibroblastic tumor
displayName	TPM4(2-222)insV-ALK(1059-1620) fusion [cytosol]
endCoordinate	222
hasModifiedResidue	[FragmentInsertionModification:9710844] Insertion of residues 1059 to 1620 at 223 from UniProt:Q9UM73 ALK [FragmentReplacedModification:9710849] Replacement of residues 222 to 222 by EV
inDisease	true
literatureReference	[LiteratureReference:9710811] TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors
maxDepth	1
memberOf	[CandidateSet:R-HSA-9700080] ALK fusion proteins [cytosol] - Homo sapiens
modified	[InstanceEdit:9832533] Orlic-Milacic, Marija, 2023-04-02
name	TPM4(2-222)insV-ALK(1059-1620) fusion Tropomyosin alpha-4 chain TPM4_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:P67936] UniProt:P67936 TPM4
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9710851
startCoordinate	2
updateTrackers	[UpdateTracker:9905433] Update Tracker - [EntityWithAccessionedSequence:9710851] TPM4(2-222)insV-ALK(1059-1620) fusion [cytosol] - v85:[modifyEndCoordinate, modifyName]

(updatedInstance)	[UpdateTracker:9905433] Update Tracker - [EntityWithAccessionedSequence:9710851] TPM4(2-222)insV-ALK(1059-1620) fusion [cytosol] - v85:[modifyEndCoordinate, modifyName]
(hasMember)	[CandidateSet:R-HSA-9700080] ALK fusion proteins [cytosol]
(hasComponent)	[Complex:R-HSA-9710895] TPM4(2-221)-ALK(1059-1620) fusion dimer [cytosol]

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