Reactome | ATIC(1-230)-ALK(1059-1620) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

ATIC(1-230)-ALK(1059-1620) fusion [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9710897] ATIC(1-230)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9710897] ATIC(1-230)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:9710843] Rothfels, Karen, 2021-01-05
crossReference	[DatabaseIdentifier:12020842] Mondo:0020325 [DatabaseIdentifier:9711753] COSMIC:COSF446 [DatabaseIdentifier:9711757] COSMIC:COSF444
dbId	9710832
disease	[Disease:9699595] anaplastic large cell lymphoma
displayName	ATIC(1-230)-ALK(1059-1620) fusion [cytosol]
endCoordinate	230
hasModifiedResidue	[FragmentInsertionModification:9710840] Insertion of residues 1059 to 1620 at 231 from UniProt:Q9UM73 ALK
inDisease	true
literatureReference	[LiteratureReference:9710779] Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis [LiteratureReference:9710719] A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma
maxDepth	1
memberOf	[CandidateSet:R-HSA-9700080] ALK fusion proteins [cytosol] - Homo sapiens
modified	[InstanceEdit:9711951] Rothfels, Karen, 2021-01-13
name	ATIC(1-230)-ALK(1059-1620) fusion Bifunctional purine biosynthesis protein ATIC PUR9_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:P31939] UniProt:P31939 ATIC
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9710832
startCoordinate	1

Referrals

(hasMember)	[CandidateSet:R-HSA-9700080] ALK fusion proteins [cytosol]
(hasComponent)	[Complex:R-HSA-9710897] ATIC(1-230)-ALK(1059-1620) fusion dimer [cytosol]

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