Reactome | CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9710894] CLTC(2-1634)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9710894] CLTC(2-1634)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:9710843] Rothfels, Karen, 2021-01-05
crossReference	[DatabaseIdentifier:12021088] Mondo:0018905 [DatabaseIdentifier:9711751] COSMIC:COSF434
dbId	9710853
disease	[Disease:9632617] diffuse large B-cell lymphoma
displayName	CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol]
endCoordinate	1634
hasModifiedResidue	[FragmentInsertionModification:9710834] Insertion of residues 1059 to 1620 at 1635 from UniProt:Q9UM73 ALK [FragmentReplacedModification:9710842] Replacement of residues 1634 to 1634 by YV
inDisease	true
literatureReference	[LiteratureReference:9710741] ALK+, CD30-, CD20- large B-cell lymphoma containing anaplastic lymphoma kinase (ALK) fused to clathrin heavy chain gene (CLTC) [LiteratureReference:9710767] Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas
maxDepth	1
memberOf	[CandidateSet:R-HSA-9700080] ALK fusion proteins [cytosol] - Homo sapiens
modified	[InstanceEdit:9832523] Orlic-Milacic, Marija, 2023-04-02
name	CLTC(2-1634)insV-ALK(1059-1620) fusion fullName evidence="36 37"Clathrin heavy chain 1 CLH1_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:Q00610] UniProt:Q00610 CLTC
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9710853
startCoordinate	2
updateTrackers	[UpdateTracker:9905480] Update Tracker - [EntityWithAccessionedSequence:9710853] CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] - v85:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9905480] Update Tracker - [EntityWithAccessionedSequence:9710853] CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] - v85:[modifyName]
(hasMember)	[CandidateSet:R-HSA-9700080] ALK fusion proteins [cytosol]
(hasComponent)	[Complex:R-HSA-9710894] CLTC(2-1634)-ALK(1059-1620) fusion dimer [cytosol]

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