Reactome | RUNX2 regulates osteoblast differentiation

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RUNX2 regulates osteoblast differentiation Show undefined attributes

authored	[InstanceEdit:8940974] Orlic-Milacic, Marija, 2016-09-27
created	[InstanceEdit:8940974] Orlic-Milacic, Marija, 2016-09-27
dbId	8940973
displayName	RUNX2 regulates osteoblast differentiation
edited	[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8941326] RUNX2 regulates bone development - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8877902] Activated AR binds RUNX2 - Homo sapiens [Reaction:R-HSA-9008877] RUNX2:CBFB binds BGLAP gene promoter - Homo sapiens [Reaction:R-HSA-8984994] RUNX2 binds MAF - Homo sapiens [Reaction:R-HSA-8877918] RUNX2:MAF complex binds the BGLAP gene promoter - Homo sapiens [Reaction:R-HSA-2064932] WWTR1 (TAZ) binds RUNX2 - Homo sapiens [Reaction:R-HSA-8985227] The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter - Homo sapiens [Reaction:R-HSA-8985460] RUNX2 binds RB1 - Homo sapiens [Reaction:R-HSA-8985485] RUNX2 and RB1 bind the BGLAP gene promoter - Homo sapiens [Reaction:R-HSA-9009208] Activated ERKs phosphorylate RUNX2 - Homo sapiens [Reaction:R-HSA-8937820] SRC,YES1 bind YAP1 - Homo sapiens [Reaction:R-HSA-8937844] SRC,YES1 phosphorylate YAP1 - Homo sapiens [Reaction:R-HSA-8937856] p-Y-YAP1 translocates to the nucleus - Homo sapiens [Reaction:R-HSA-8937864] RUNX2 binds tyrosine phosphorylated YAP1 - Homo sapiens [Reaction:R-HSA-8937869] RUNX2:CBFB:p-Y-YAP1 binds the BGLAP gene promoter - Homo sapiens [Reaction:R-HSA-9008137] RUNX2 binds ZNF521 and HDAC3 - Homo sapiens [Reaction:R-HSA-9008177] RUNX2 binds HEY1,HEY2,HES1 - Homo sapiens [BlackBoxEvent:R-HSA-8877922] BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521 - Homo sapiens [Reaction:R-HSA-8939852] RUNX2 and SP7 bind the UCMA gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8939870] UCMA gene expression is stimulated by RUNX2 and SP7 - Homo sapiens [Reaction:R-HSA-8985275] RUNX2 binds to SATB2 - Homo sapiens [Reaction:R-HSA-8985627] RUNX2 and RB1 bind the COL1A1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8985644] COL1A1 gene expression is stimulated by RUNX2 and RB1 - Homo sapiens [Reaction:R-HSA-9008215] RUNX2 binds GLI3R - Homo sapiens [Reaction:R-HSA-9008389] RUNX2 binds HDAC6 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8877901] Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA [LiteratureReference:8939864] Ucma, a direct transcriptional target of Runx2 and Osterix, promotes osteoblast differentiation and nodule formation [LiteratureReference:8937884] Decreased c-Src expression enhances osteoblast differentiation and bone formation [LiteratureReference:8939697] Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2 [LiteratureReference:8937826] Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription [LiteratureReference:9015233] Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation [LiteratureReference:9015269] Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene [LiteratureReference:9015275] Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication [LiteratureReference:9015268] Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation
maxDepth	2
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	RUNX2 regulates osteoblast differentiation
orthologousEvent	[Pathway:R-CFA-8940973] RUNX2 regulates osteoblast differentiation - Canis familiaris [Pathway:R-DME-8940973] RUNX2 regulates osteoblast differentiation - Drosophila melanogaster [Pathway:R-GGA-8940973] RUNX2 regulates osteoblast differentiation - Gallus gallus [Pathway:R-XTR-8940973] RUNX2 regulates osteoblast differentiation - Xenopus tropicalis [Pathway:R-DRE-8940973] RUNX2 regulates osteoblast differentiation - Danio rerio [Pathway:R-SSC-8940973] RUNX2 regulates osteoblast differentiation - Sus scrofa [Pathway:R-BTA-8940973] RUNX2 regulates osteoblast differentiation - Bos taurus [Pathway:R-MMU-8940973] RUNX2 regulates osteoblast differentiation - Mus musculus
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8940973
summation	[Summation:8941341] The complex of RUNX2 and CBFB regulates transcription of gen...

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[Pathway:R-HSA-8941326] RUNX2 regulates bone development

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