Reactome | RUNX2 regulates bone development

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RUNX2 regulates bone development Show undefined attributes

authored	[InstanceEdit:8941327] Orlic-Milacic, Marija, 2016-09-30
created	[InstanceEdit:8941327] Orlic-Milacic, Marija, 2016-09-30
dbId	8941326
displayName	RUNX2 regulates bone development
edited	[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation - Homo sapiens [Pathway:R-HSA-8941284] RUNX2 regulates chondrocyte maturation - Homo sapiens [Reaction:R-HSA-8938356] RMB14 binds RUNX2 - Homo sapiens [Reaction:R-HSA-8877941] RUNX2 binds SMAD1 in the nucleus - Homo sapiens [Reaction:R-HSA-8878013] RUNX2 and SMAD1 complex binds the SMAD6 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8878023] SMAD6 gene expression is stimulated by RUNX2 and SMAD1 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8878262] Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog [LiteratureReference:8938348] Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors [LiteratureReference:9015211] Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia [LiteratureReference:9015201] Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development [LiteratureReference:9015224] Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts [LiteratureReference:9015233] Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation [LiteratureReference:9015235] Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
maxDepth	3
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RUNX2 regulates bone development
orthologousEvent	[Pathway:R-CFA-8941326] RUNX2 regulates bone development - Canis familiaris [Pathway:R-CEL-8941326] RUNX2 regulates bone development - Caenorhabditis elegans [Pathway:R-DME-8941326] RUNX2 regulates bone development - Drosophila melanogaster [Pathway:R-GGA-8941326] RUNX2 regulates bone development - Gallus gallus [Pathway:R-XTR-8941326] RUNX2 regulates bone development - Xenopus tropicalis [Pathway:R-DRE-8941326] RUNX2 regulates bone development - Danio rerio [Pathway:R-SSC-8941326] RUNX2 regulates bone development - Sus scrofa [Pathway:R-BTA-8941326] RUNX2 regulates bone development - Bos taurus [Pathway:R-MMU-8941326] RUNX2 regulates bone development - Mus musculus
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8941326
summation	[Summation:8941356] RUNX2 is required for the development of both intramembraneo...

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[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2

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