Reactome | Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

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Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription Show undefined attributes

author	[Person:3319441] Zaidi, SK [Person:8937822] Sullivan, AJ [Person:3319437] Medina, R [Person:2028657] Ito, Y [Person:8877896] van Wijnen, AJ [Person:3319429] Stein, JL [Person:3319435] Lian, JB [Person:3319444] Stein, GS
created	[InstanceEdit:8937824] Orlic-Milacic, Marija, 2016-09-06
dbId	8937826
displayName	Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
journal	EMBO J.
pages	790-9
pubMedIdentifier	14765127
schemaClass	LiteratureReference
title	Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
url	http://www.ncbi.nlm.nih.gov/pubmed/14765127
volume	23
year	2004

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(literatureReference)

[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation
[Summation:8877929] Binding of RUNX2 to the OSE2 element in the promoter of the ...
[BlackBoxEvent:R-HSA-8877922] BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521
[BlackBoxEvent:R-RNO-8937955] Bglap gene expression is negatively regulated by Yap1
[RegulationReference:9642897] Negative gene expression regulation by 'Runx2:Cbfb:p-Y-Yap1:Bglap gene [nucleoplasm]' Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
[RegulationReference:9641648] Negative gene expression regulation by 'RUNX2:CBFB:p-Y-YAP1:BGLAP gene [nucleoplasm]' Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
[Reaction:R-HSA-8937869] RUNX2:CBFB:p-Y-YAP1 binds the BGLAP gene promoter
[Reaction:R-RNO-8937949] Runx2:Cbfb:p-Y-Yap1 binds the Bglap gene promoter
[Complex:R-RNO-8937950] Runx2:Cbfb:p-Y-Yap1:Bglap gene [nucleoplasm]
[Complex:R-HSA-8937871] RUNX2:CBFB:p-Y-YAP1:BGLAP gene [nucleoplasm]
[Reaction:R-HSA-8937864] RUNX2 binds tyrosine phosphorylated YAP1
[Reaction:R-RNO-8937926] Runx2 binds p-Y-Yap1
[Complex:R-RNO-8937929] Runx2:Cbfb:p-Y-Yap1 [nucleoplasm]
[Reaction:R-HSA-8937856] p-Y-YAP1 translocates to the nucleus
[Reaction:R-RNO-8937920] p-Y-Yap1 translocates to the nucleus
[Reaction:R-HSA-8937844] SRC,YES1 phosphorylate YAP1
[Reaction:R-RNO-8937915] Src,Yes1 phosphorylate Yap1
[Reaction:R-HSA-8937820] SRC,YES1 bind YAP1
[Reaction:R-RNO-8937895] Src,Yes1 bind Yap1
[CatalystActivityReference:9644022] protein tyrosine kinase activity of MyrG-p-Y419-SRC,MyrG-p-Y426-YES1:YAP1 [plasma membrane] Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
[Complex:R-HSA-8937821] MyrG-p-Y419-SRC,MyrG-p-Y426-YES1:YAP1 [plasma membrane]
[Complex:R-HSA-8937863] RUNX2:CBFB:p-Y-YAP1 [nucleoplasm]

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