Reactome | RUNX2 binds RB1

Schema > Reaction > Entries

authored	[InstanceEdit:8985468] Orlic-Milacic, Marija, 2017-04-17
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8985468] Orlic-Milacic, Marija, 2017-04-17
dbId	8985460
displayName	RUNX2 binds RB1
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation - Homo sapiens
followingEvent	[Reaction:R-HSA-8985627] RUNX2 and RB1 bind the COL1A1 gene promoter - Homo sapiens [Reaction:R-HSA-8985485] RUNX2 and RB1 bind the BGLAP gene promoter - Homo sapiens
inferredFrom	[Reaction:R-NUL-8985474] Runx2 binds RB1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-68642] RB1 [nucleoplasm] [CandidateSet:R-HSA-9007751] RUNX2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8985461] The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX2 binds RB1
output	[Complex:R-HSA-8985470] RUNX2:RB1 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9007999] RUNX2 translocates to the nucleus - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8985460
summation	[Summation:8985466] RUNX2 forms a complex with the tumor suppressor RB1. The C-t...

(hasEvent)	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation
(precedingEvent)	[Reaction:R-HSA-8985627] RUNX2 and RB1 bind the COL1A1 gene promoter [Reaction:R-HSA-8985485] RUNX2 and RB1 bind the BGLAP gene promoter
(inferredTo)	[Reaction:R-NUL-8985474] Runx2 binds RB1

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