Reactome | RUNX2:MAF complex binds the BGLAP gene promoter

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RUNX2:MAF complex binds the BGLAP gene promoter Show undefined attributes

authored	[InstanceEdit:8877915] Orlic-Milacic, Marija, 2016-06-28
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8877915] Orlic-Milacic, Marija, 2016-06-28
dbId	8877918
displayName	RUNX2:MAF complex binds the BGLAP gene promoter
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8877922] BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521 - Homo sapiens
inferredFrom	[Reaction:R-MMU-8985018] Runx2:Maf binds the Bglap gene promoter - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-8877914] BGLAP gene [nucleoplasm] [Complex:R-HSA-8984995] RUNX2:MAF [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8877901] Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA [LiteratureReference:8985000] Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX2:MAF complex binds the BGLAP gene promoter
output	[Complex:R-HSA-8877917] RUNX2:MAF:BGLAP gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8984994] RUNX2 binds MAF - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8877921] Negative regulation by 'RUNX2:AR:androgen [nucleoplasm]'
regulationReference	[RegulationReference:9641741] Negative regulation by 'RUNX2:AR:androgen [nucleoplasm]' Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8877918
summation	[Summation:8877927] RUNX2 binds the OSE2 element in the promoter of the BGLAP (o...

Referrals

(hasEvent)	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation
(precedingEvent)	[BlackBoxEvent:R-HSA-8877922] BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521
(inferredTo)	[Reaction:R-MMU-8985018] Runx2:Maf binds the Bglap gene promoter