Reactome | Activated ERKs phosphorylate RUNX2

Schema > Reaction > Entries

Activated ERKs phosphorylate RUNX2 Show undefined attributes

authored	[InstanceEdit:9009205] Orlic-Milacic, Marija, 2017-06-15
catalystActivity	[CatalystActivity:198713] protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9009205] Orlic-Milacic, Marija, 2017-06-15
dbId	9009208
displayName	Activated ERKs phosphorylate RUNX2
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation - Homo sapiens
followingEvent	[Reaction:R-HSA-9008877] RUNX2:CBFB binds BGLAP gene promoter - Homo sapiens
inferredFrom	[Reaction:R-NUL-9009236] Activated ERKs phosphorylate Runx2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-8865420] RUNX2:CBFB [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9009204] Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated ERKs phosphorylate RUNX2
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-9009233] p-2S-RUNX2:CBFB [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8865425] RUNX2 binds CBFB - Homo sapiens [BlackBoxEvent:R-HSA-5674387] Phosphorylated MAPKs translocate into the nucleus - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9009208
summation	[Summation:9009254] RUNX2 is phosphorylated by activated ERKs (MAPK3 and MAPK1) ...

Referrals

(hasEvent)	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation
(precedingEvent)	[Reaction:R-HSA-9008877] RUNX2:CBFB binds BGLAP gene promoter
(inferredTo)	[Reaction:R-NUL-9009236] Activated ERKs phosphorylate Runx2

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