Reactome | RUNX2 binds GLI3R

Schema > Reaction > Entries

authored	[InstanceEdit:9008213] Orlic-Milacic, Marija, 2017-06-07
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9008213] Orlic-Milacic, Marija, 2017-06-07
dbId	9008215
displayName	RUNX2 binds GLI3R
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation - Homo sapiens
inferredFrom	[Reaction:R-MMU-9008236] Runx2 binds Gli3r - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-5610371] GLI3R [nucleoplasm] [CandidateSet:R-HSA-9007751] RUNX2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9008224] Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX2 binds GLI3R
output	[Complex:R-HSA-9008227] RUNX2:GLI3R [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-5610752] GLI3R translocates to the nucleus - Homo sapiens [BlackBoxEvent:R-HSA-9007999] RUNX2 translocates to the nucleus - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9008215
summation	[Summation:9008233] Based on studies in mice, GLI3R, a repressive form of GLI3 g...

(hasEvent)	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation
(inferredTo)	[Reaction:R-MMU-9008236] Runx2 binds Gli3r

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