Reactome | SRC,YES1 phosphorylate YAP1

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SRC,YES1 phosphorylate YAP1 Show undefined attributes

authored	[InstanceEdit:8937845] Orlic-Milacic, Marija, 2016-09-07
catalystActivity	[CatalystActivity:8937852] protein tyrosine kinase activity of MyrG-p-Y419-SRC,MyrG-p-Y426-YES1:YAP1 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9644022] protein tyrosine kinase activity of MyrG-p-Y419-SRC,MyrG-p-Y426-YES1:YAP1 [plasma membrane] Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8937845] Orlic-Milacic, Marija, 2016-09-07
dbId	8937844
displayName	SRC,YES1 phosphorylate YAP1
edited	[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation - Homo sapiens
followingEvent	[Reaction:R-HSA-8937856] p-Y-YAP1 translocates to the nucleus - Homo sapiens
inferredFrom	[Reaction:R-RNO-8937915] Src,Yes1 phosphorylate Yap1 - Rattus norvegicus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-8937821] MyrG-p-Y419-SRC,MyrG-p-Y426-YES1:YAP1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8937826] Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SRC,YES1 phosphorylate YAP1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-8937825] MyrG-p-Y419-SRC,MyrG-p-Y426-YES1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-8937843] p-Y-YAP1 [cytosol]
precedingEvent	[Reaction:R-HSA-8937820] SRC,YES1 bind YAP1 - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8937844
summation	[Summation:8937850] Based on studies in rat, activated SRC and/or YES1 tyrosine ...

Referrals

(hasEvent)	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation
(precedingEvent)	[Reaction:R-HSA-8937856] p-Y-YAP1 translocates to the nucleus
(inferredTo)	[Reaction:R-RNO-8937915] Src,Yes1 phosphorylate Yap1

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