Reactome | RUNX2 binds HDAC6

Schema > Reaction > Entries

authored	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9008388] Orlic-Milacic, Marija, 2017-06-09
dbId	9008389
displayName	RUNX2 binds HDAC6
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation - Homo sapiens
followingEvent	[Reaction:R-HSA-9008433] RUNX2 binds CDKN1A gene promoter - Homo sapiens
inferredFrom	[Reaction:R-RNO-9008394] Runx2 binds Hdac6 - Rattus norvegicus
input	[EntityWithAccessionedSequence:R-HSA-351589] HDAC6 [nucleoplasm] [CandidateSet:R-HSA-9007751] RUNX2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9008386] Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX2 binds HDAC6
output	[Complex:R-HSA-9008392] RUNX2:HDAC6 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9007999] RUNX2 translocates to the nucleus - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9008389
summation	[Summation:9008393] Based on studies in rat osteoblast, RUNX2 forms a complex wi...

(precedingEvent)	[Reaction:R-HSA-9008433] RUNX2 binds CDKN1A gene promoter
(hasEvent)	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation
(inferredTo)	[Reaction:R-RNO-9008394] Runx2 binds Hdac6

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