Reactome | COL1A1 gene expression is stimulated by RUNX2 and RB1

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COL1A1 gene expression is stimulated by RUNX2 and RB1 Show undefined attributes

authored	[InstanceEdit:8985646] Orlic-Milacic, Marija, 2017-04-18
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:984] extracellular region
created	[InstanceEdit:8985646] Orlic-Milacic, Marija, 2017-04-18
dbId	8985644
displayName	COL1A1 gene expression is stimulated by RUNX2 and RB1
edited	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
eventOf	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-8985650] Col1a1 gene expression is stimulated by Runx2 and Rb1 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-8985634] COL1A1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8985616] Rb regulates fate choice and lineage commitment in vivo [LiteratureReference:9016594] Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	COL1A1 gene expression is stimulated by RUNX2 and RB1
output	[EntityWithAccessionedSequence:R-HSA-51125] COL1A1 [extracellular region]
precedingEvent	[Reaction:R-HSA-8985627] RUNX2 and RB1 bind the COL1A1 gene promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-8985649] Positive gene expression regulation by 'RUNX2:RB1:COL1A1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9641561] Positive gene expression regulation by 'RUNX2:RB1:COL1A1 gene [nucleoplasm]' Rb regulates fate choice and lineage commitment in vivo
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8985644
summation	[Summation:8985645] Based on mouse studies, binding of the RUNX2:RB1 complex to ...

Referrals

(hasEvent)	[Pathway:R-HSA-8940973] RUNX2 regulates osteoblast differentiation
(inferredTo)	[BlackBoxEvent:R-MMU-8985650] Col1a1 gene expression is stimulated by Runx2 and Rb1

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