Reactome | Interferon gamma signaling

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Interferon gamma signaling Show undefined attributes

authored	[InstanceEdit:873929] Garapati, P V, 2010-06-08
created	[InstanceEdit:877278] Garapati, P V, 2010-06-11
crossReference	[DatabaseIdentifier:12819653] BioModels Database:BIOMD0000001077 [DatabaseIdentifier:12819657] BioModels Database:BIOMD0000000313 [DatabaseIdentifier:12819649] BioModels Database:BIOMD0000000968 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	877300
displayName	Interferon gamma signaling
edited	[InstanceEdit:873929] Garapati, P V, 2010-06-08
eventOf	[Pathway:R-HSA-913531] Interferon Signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:383450] type II interferon-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-873926] IFNG dimer binds IFNGR - Homo sapiens [Reaction:R-HSA-9678561] IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors - Homo sapiens [Reaction:R-HSA-9689680] IFNG dimer binds IFNG inhibitors - Homo sapiens [Reaction:R-HSA-873919] Phosphorylation of JAK2 - Homo sapiens [Reaction:R-HSA-873918] Transphosphorylation of JAK1 - Homo sapiens [Reaction:R-HSA-873924] Phosphorylation of IFNGR1 by JAK kinases - Homo sapiens [BlackBoxEvent:R-HSA-9734547] JAK2-activated MAPKs phosphorylate YBX1 - Homo sapiens [BlackBoxEvent:R-HSA-9736836] Phosphorylated YBX1 translocates to the nucleus - Homo sapiens [Reaction:R-HSA-873921] Binding of STAT1 to p-IFNGR1 - Homo sapiens [Reaction:R-HSA-873922] Phosphorylation of STAT1 by JAK kinases - Homo sapiens [Reaction:R-HSA-909552] Phosphorylation of STAT1 at Ser727 - Homo sapiens [Reaction:R-HSA-873927] Release of STAT1 dimer from active receptor unit - Homo sapiens [BlackBoxEvent:R-HSA-873917] Translocation of STAT1 dimer to nucleus - Homo sapiens [Reaction:R-HSA-1031713] GAF binds the GAS promoter elements in the IFNG-regulated genes - Homo sapiens [BlackBoxEvent:R-HSA-1031716] Expression of IFNG-stimulated genes - Homo sapiens [BlackBoxEvent:R-HSA-9730967] STAT1 stimulates SMAD7 gene transcription - Homo sapiens [Pathway:R-HSA-877312] Regulation of IFNG signaling - Homo sapiens [Pathway:R-HSA-9732724] IFNG signaling activates MAPKs - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-06-07
literatureReference	[LiteratureReference:873893] IFNgamma signaling-does it mean JAK-STAT? [LiteratureReference:873880] The interferon gamma (IFN-gamma) receptor: a paradigm for the multichain cytokine receptor [LiteratureReference:873861] The IFN gamma receptor: a paradigm for cytokine receptor signaling [LiteratureReference:873858] Interferon-gamma: an overview of signals, mechanisms and functions
maxDepth	3
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Interferon gamma signaling
orthologousEvent	[Pathway:R-RNO-877300] Interferon gamma signaling - Rattus norvegicus [Pathway:R-CFA-877300] Interferon gamma signaling - Canis familiaris [Pathway:R-BTA-877300] Interferon gamma signaling - Bos taurus [Pathway:R-SSC-877300] Interferon gamma signaling - Sus scrofa [Pathway:R-DRE-877300] Interferon gamma signaling - Danio rerio [Pathway:R-XTR-877300] Interferon gamma signaling - Xenopus tropicalis [Pathway:R-GGA-877300] Interferon gamma signaling - Gallus gallus [Pathway:R-DME-877300] Interferon gamma signaling - Drosophila melanogaster [Pathway:R-CEL-877300] Interferon gamma signaling - Caenorhabditis elegans [Pathway:R-DDI-877300] Interferon gamma signaling - Dictyostelium discoideum [Pathway:R-MMU-877300] Interferon gamma signaling - Mus musculus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17 [InstanceEdit:9928383] Matthews, Lisa, 2024-11-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-877300
summation	[Summation:873842] Interferon-gamma (IFN-gamma) belongs to the type II interfer...
updateTrackers	[UpdateTracker:9779899] Update Tracker - [Pathway:877300] Interferon gamma signaling - v64:[updateContainedRLE] [UpdateTracker:9782355] Update Tracker - [Pathway:877300] Interferon gamma signaling - v59:[updateContainedPathway] [UpdateTracker:9788390] Update Tracker - [Pathway:877300] Interferon gamma signaling - v42:[updateContainedRLE] [UpdateTracker:9777037] Update Tracker - [Pathway:877300] Interferon gamma signaling - v73:[updateContainedRLE] [UpdateTracker:9775344] Update Tracker - [Pathway:877300] Interferon gamma signaling - v79:[updateContainedRLE] [UpdateTracker:9776833] Update Tracker - [Pathway:877300] Interferon gamma signaling - v74:[addHasEvent, updateContainedRLE] [UpdateTracker:9785824] Update Tracker - [Pathway:877300] Interferon gamma signaling - v51:[updateContainedRLE] [UpdateTracker:9835767] Update Tracker - [Pathway:877300] Interferon gamma signaling - v85:[addHasEvent] [UpdateTracker:9774805] Update Tracker - [Pathway:877300] Interferon gamma signaling - v81:[addHasEvent]

Referrals

(hasEvent)	[Pathway:R-HSA-913531] Interferon Signaling
(hasEncapsulatedEvent)	[Pathway:R-HSA-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
(updatedInstance)	[UpdateTracker:9779899] Update Tracker - [Pathway:877300] Interferon gamma signaling - v64:[updateContainedRLE] [UpdateTracker:9782355] Update Tracker - [Pathway:877300] Interferon gamma signaling - v59:[updateContainedPathway] [UpdateTracker:9788390] Update Tracker - [Pathway:877300] Interferon gamma signaling - v42:[updateContainedRLE] [UpdateTracker:9777037] Update Tracker - [Pathway:877300] Interferon gamma signaling - v73:[updateContainedRLE] [UpdateTracker:9775344] Update Tracker - [Pathway:877300] Interferon gamma signaling - v79:[updateContainedRLE] [UpdateTracker:9776833] Update Tracker - [Pathway:877300] Interferon gamma signaling - v74:[addHasEvent, updateContainedRLE] [UpdateTracker:9785824] Update Tracker - [Pathway:877300] Interferon gamma signaling - v51:[updateContainedRLE] [UpdateTracker:9835767] Update Tracker - [Pathway:877300] Interferon gamma signaling - v85:[addHasEvent] [UpdateTracker:9774805] Update Tracker - [Pathway:877300] Interferon gamma signaling - v81:[addHasEvent]

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