Reactome | JAK2-activated MAPKs phosphorylate YBX1

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JAK2-activated MAPKs phosphorylate YBX1 Show undefined attributes

authored	[InstanceEdit:9753487] Orlic-Milacic, Marija, 2021-09-07
catalystActivity	[CatalystActivity:4793923] protein serine/threonine kinase activity of p-T,Y MAPK dimers [cytosol]
category	uncertain
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9734549] Orlic-Milacic, Marija, 2021-06-17
dbId	9734547
displayName	JAK2-activated MAPKs phosphorylate YBX1
edited	[InstanceEdit:9833712] Matthews, Lisa, 2023-05-02
eventOf	[Pathway:R-HSA-877300] Interferon gamma signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9736836] Phosphorylated YBX1 translocates to the nucleus - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-9736840] YBX1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	JAK2-activated MAPKs phosphorylate YBX1
orthologousEvent	[BlackBoxEvent:R-CEL-9734547] JAK2-activated MAPKs phosphorylate YBX1 - Caenorhabditis elegans [BlackBoxEvent:R-DME-9734547] JAK2-activated MAPKs phosphorylate YBX1 - Drosophila melanogaster [BlackBoxEvent:R-GGA-9734547] JAK2-activated MAPKs phosphorylate YBX1 - Gallus gallus [BlackBoxEvent:R-XTR-9734547] JAK2-activated MAPKs phosphorylate YBX1 - Xenopus tropicalis [BlackBoxEvent:R-DRE-9734547] JAK2-activated MAPKs phosphorylate YBX1 - Danio rerio [BlackBoxEvent:R-SSC-9734547] JAK2-activated MAPKs phosphorylate YBX1 - Sus scrofa [BlackBoxEvent:R-BTA-9734547] JAK2-activated MAPKs phosphorylate YBX1 - Bos taurus [BlackBoxEvent:R-CFA-9734547] JAK2-activated MAPKs phosphorylate YBX1 - Canis familiaris [BlackBoxEvent:R-RNO-9734547] JAK2-activated MAPKs phosphorylate YBX1 - Rattus norvegicus [BlackBoxEvent:R-MMU-9734547] JAK2-activated MAPKs phosphorylate YBX1 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-9736837] p-S32,S36-YBX1 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9732753] JAK1-activated RAF1 phosphorylates MAPKs - Homo sapiens [Reaction:R-HSA-873918] Transphosphorylation of JAK1 - Homo sapiens
regulatedBy	[PositiveRegulation:9737539] Positive regulation by 'IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane]'
releaseDate	2023-06-07
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9734547
summation	[Summation:9737543] Interferon-gamma (IFNG) signaling was shown to induce nuclea...

Referrals

(hasEvent)	[Pathway:R-HSA-877300] Interferon gamma signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-9736836] Phosphorylated YBX1 translocates to the nucleus