Reactome | IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors

Schema > Reaction > Entries

IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors Show undefined attributes

authored	[InstanceEdit:9678968] Jassal, Bijay, 2020-03-23
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9678557] Jassal, Bijay, 2020-03-23
dbId	9678561
definition	Inhibition
displayName	IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
edited	[InstanceEdit:9678968] Jassal, Bijay, 2020-03-23
eventOf	[Pathway:R-HSA-877300] Interferon gamma signaling - Homo sapiens [Pathway:R-HSA-9679191] Potential therapeutics for SARS - Homo sapiens
input	[Complex:R-HSA-873810] IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] [DefinedSet:R-ALL-9678984] JAK1,2 inhibitors [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9678565] Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors [LiteratureReference:9678583] Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050 [LiteratureReference:9678571] Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms [LiteratureReference:9678541] Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
orthologousEvent	[Reaction:R-MMU-9678561] IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors - Mus musculus [Reaction:R-GGA-9678561] IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors - Gallus gallus [Reaction:R-XTR-9678561] IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors - Xenopus tropicalis [Reaction:R-DRE-9678561] IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors - Danio rerio [Reaction:R-SSC-9678561] IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors - Sus scrofa [Reaction:R-BTA-9678561] IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors - Bos taurus [Reaction:R-CFA-9678561] IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors - Canis familiaris [Reaction:R-RNO-9678561] IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors - Rattus norvegicus
output	[Complex:R-HSA-9678548] IFNGR1:JAK1:INFGR2:JAK2:JAK1,2 inhibitors [plasma membrane]
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9688552] Shoichet, Brian, 2020-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9678561
summation	[Summation:9686366] Janus Kinase 2 (JAK2) binds and is inhibited by several smal...
updateTrackers	[UpdateTracker:9776791] Update Tracker - [Reaction:9678561] IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors - v74:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9776791] Update Tracker - [Reaction:9678561] IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors - v74:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-9679191] Potential therapeutics for SARS [Pathway:R-HSA-877300] Interferon gamma signaling