Reactome | Translocation of STAT1 dimer to nucleus

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Translocation of STAT1 dimer to nucleus Show undefined attributes

authored	[InstanceEdit:873929] Garapati, P V, 2010-06-08
category	omitted
compartment	[Compartment:13231] nuclear envelope
created	[InstanceEdit:873929] Garapati, P V, 2010-06-08
dbId	873917
displayName	Translocation of STAT1 dimer to nucleus
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
eventOf	[Pathway:R-HSA-877300] Interferon gamma signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9942683] p-STAT1 and NFATC1 bind the TBX21 gene - Homo sapiens [Reaction:R-HSA-1031713] GAF binds the GAS promoter elements in the IFNG-regulated genes - Homo sapiens [Reaction:R-HSA-997326] Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP - Homo sapiens [Reaction:R-HSA-877281] PIAS1 binds p-STAT1 dimer - Homo sapiens [BlackBoxEvent:R-HSA-9730967] STAT1 stimulates SMAD7 gene transcription - Homo sapiens
input	[Complex:R-HSA-873827] IFNG-activated factor (GAF) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:873866] Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions [LiteratureReference:873910] Regulation of STAT1 nuclear export by Jak1 [LiteratureReference:933495] The ins and outs of STAT1 nuclear transport
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Translocation of STAT1 dimer to nucleus
orthologousEvent	[BlackBoxEvent:R-DDI-873917] Translocation of STAT1 dimer to nucleus - Dictyostelium discoideum [BlackBoxEvent:R-CEL-873917] Translocation of STAT1 dimer to nucleus - Caenorhabditis elegans [BlackBoxEvent:R-DME-873917] Translocation of STAT1 dimer to nucleus - Drosophila melanogaster [BlackBoxEvent:R-GGA-873917] Translocation of STAT1 dimer to nucleus - Gallus gallus [BlackBoxEvent:R-XTR-873917] Translocation of STAT1 dimer to nucleus - Xenopus tropicalis [BlackBoxEvent:R-DRE-873917] Translocation of STAT1 dimer to nucleus - Danio rerio [BlackBoxEvent:R-SSC-873917] Translocation of STAT1 dimer to nucleus - Sus scrofa [BlackBoxEvent:R-BTA-873917] Translocation of STAT1 dimer to nucleus - Bos taurus [BlackBoxEvent:R-CFA-873917] Translocation of STAT1 dimer to nucleus - Canis familiaris [BlackBoxEvent:R-RNO-873917] Translocation of STAT1 dimer to nucleus - Rattus norvegicus [BlackBoxEvent:R-MMU-873917] Translocation of STAT1 dimer to nucleus - Mus musculus
output	[Complex:R-HSA-873824] p-STAT1 homodimer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-873927] Release of STAT1 dimer from active receptor unit - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-873917
summation	[Summation:873846] Released GAF complex translocates to the nucleus and binds t...

Referrals

(precedingEvent)	[Reaction:R-HSA-9942683] p-STAT1 and NFATC1 bind the TBX21 gene [Reaction:R-HSA-1031713] GAF binds the GAS promoter elements in the IFNG-regulated genes [Reaction:R-HSA-997326] Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP [Reaction:R-HSA-877281] PIAS1 binds p-STAT1 dimer [BlackBoxEvent:R-HSA-9730967] STAT1 stimulates SMAD7 gene transcription
(hasEvent)	[Pathway:R-HSA-877300] Interferon gamma signaling

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