Reactome | Phosphorylation of STAT1 at Ser727

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Phosphorylation of STAT1 at Ser727 Show undefined attributes

authored	[InstanceEdit:873929] Garapati, P V, 2010-06-08
catalystActivity	[CatalystActivity:909567] diacylglycerol-dependent, calcium-independent serine/threonine kinase activity of CaMKII and PKC-delta [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:909562] Garapati, P V, 2010-07-07
dbId	909552
displayName	Phosphorylation of STAT1 at Ser727
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
eventOf	[Pathway:R-HSA-877300] Interferon gamma signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-873927] Release of STAT1 dimer from active receptor unit - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-873817] p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:909560] Protein kinase Cdelta regulates apoptosis via activation of STAT1 [LiteratureReference:909553] Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Phosphorylation of STAT1 at Ser727
orthologousEvent	[Reaction:R-GGA-909552] Phosphorylation of STAT1 at Ser727 - Gallus gallus [Reaction:R-DRE-909552] Phosphorylation of STAT1 at Ser727 - Danio rerio [Reaction:R-SSC-909552] Phosphorylation of STAT1 at Ser727 - Sus scrofa [Reaction:R-BTA-909552] Phosphorylation of STAT1 at Ser727 - Bos taurus [Reaction:R-CFA-909552] Phosphorylation of STAT1 at Ser727 - Canis familiaris [Reaction:R-RNO-909552] Phosphorylation of STAT1 at Ser727 - Rattus norvegicus [Reaction:R-MMU-909552] Phosphorylation of STAT1 at Ser727 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-909556] p-STAT1 dimer bound to p-IFNGR1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-873922] Phosphorylation of STAT1 by JAK kinases - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-909552
summation	[Summation:909555] Kinases like Protein kinase C delta (PKC-delta) and Calcium/...

Referrals

(hasEvent)	[Pathway:R-HSA-877300] Interferon gamma signaling
(precedingEvent)	[Reaction:R-HSA-873927] Release of STAT1 dimer from active receptor unit

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