Reactome | Binding of STAT1 to p-IFNGR1

Schema > Reaction > Entries

Binding of STAT1 to p-IFNGR1 Show undefined attributes

authored	[InstanceEdit:873929] Garapati, P V, 2010-06-08
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:873929] Garapati, P V, 2010-06-08
dbId	873921
displayName	Binding of STAT1 to p-IFNGR1
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
eventOf	[Pathway:R-HSA-877300] Interferon gamma signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-873922] Phosphorylation of STAT1 by JAK kinases - Homo sapiens
input	[Complex:R-HSA-873814] IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] 2 × [EntityWithAccessionedSequence:R-HSA-380745] STAT1-1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:507782] Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process [LiteratureReference:873881] Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91) [LiteratureReference:933486] A road map for those who don't know JAK-STAT
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Binding of STAT1 to p-IFNGR1
negativePrecedingEvent	[NegativePrecedingEvent:9754409] Futile Cycle: Release of STAT1 dimer from active receptor unit
orthologousEvent	[Reaction:R-GGA-873921] Binding of STAT1 to p-IFNGR1 - Gallus gallus [Reaction:R-DRE-873921] Binding of STAT1 to p-IFNGR1 - Danio rerio [Reaction:R-SSC-873921] Binding of STAT1 to p-IFNGR1 - Sus scrofa [Reaction:R-BTA-873921] Binding of STAT1 to p-IFNGR1 - Bos taurus [Reaction:R-CFA-873921] Binding of STAT1 to p-IFNGR1 - Canis familiaris [Reaction:R-RNO-873921] Binding of STAT1 to p-IFNGR1 - Rattus norvegicus [Reaction:R-MMU-873921] Binding of STAT1 to p-IFNGR1 - Mus musculus
output	[Complex:R-HSA-873828] STAT1 bound to p-IFNGR1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-873924] Phosphorylation of IFNGR1 by JAK kinases - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-873921
summation	[Summation:873835] The phosphorylated tyrosine residue 440 in the 440YDKPH444 m...

Referrals

(hasEvent)	[Pathway:R-HSA-877300] Interferon gamma signaling
(precedingEvent)	[Reaction:R-HSA-873922] Phosphorylation of STAT1 by JAK kinases