Reactome | Transphosphorylation of JAK1

Schema > Reaction > Entries

Transphosphorylation of JAK1 Show undefined attributes

authored	[InstanceEdit:873929] Garapati, P V, 2010-06-08
catalystActivity	[CatalystActivity:873923] protein tyrosine kinase activity of IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:873929] Garapati, P V, 2010-06-08
dbId	873918
displayName	Transphosphorylation of JAK1
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
eventOf	[Pathway:R-HSA-877300] Interferon gamma signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-877308] Dephosphorylation of JAKs by PTPs - Homo sapiens [Reaction:R-HSA-9732729] Activated JAK1 binds RAF1 - Homo sapiens [Reaction:R-HSA-873924] Phosphorylation of IFNGR1 by JAK kinases - Homo sapiens [BlackBoxEvent:R-HSA-9734547] JAK2-activated MAPKs phosphorylate YBX1 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-873811] IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:873845] Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Transphosphorylation of JAK1
orthologousEvent	[Reaction:R-GGA-873918] Transphosphorylation of JAK1 - Gallus gallus [Reaction:R-DRE-873918] Transphosphorylation of JAK1 - Danio rerio [Reaction:R-SSC-873918] Transphosphorylation of JAK1 - Sus scrofa [Reaction:R-BTA-873918] Transphosphorylation of JAK1 - Bos taurus [Reaction:R-CFA-873918] Transphosphorylation of JAK1 - Canis familiaris [Reaction:R-RNO-873918] Transphosphorylation of JAK1 - Rattus norvegicus [Reaction:R-MMU-873918] Transphosphorylation of JAK1 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-873820] IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-873919] Phosphorylation of JAK2 - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-877279] Negative regulation by 'PTPN6 [cytosol]' [NegativeRegulation:R-HSA-877306] Negative regulation by 'IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane]'
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-873918
summation	[Summation:873854] The initial phosphorylation of JAK1 and JAK2 is mediated by ...

Referrals

(hasEvent)	[Pathway:R-HSA-877300] Interferon gamma signaling
(precedingEvent)	[Reaction:R-HSA-877308] Dephosphorylation of JAKs by PTPs [BlackBoxEvent:R-HSA-9734547] JAK2-activated MAPKs phosphorylate YBX1 [Reaction:R-HSA-9732729] Activated JAK1 binds RAF1 [Reaction:R-HSA-873924] Phosphorylation of IFNGR1 by JAK kinases