Reactome | Expression of IFNG-stimulated genes

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Expression of IFNG-stimulated genes Show undefined attributes

authored	[InstanceEdit:909728] Garapati, P V, 2010-07-07
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1031717] Garapati, P V, 2010-11-18
dbId	1031716
displayName	Expression of IFNG-stimulated genes
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
eventOf	[Pathway:R-HSA-877300] Interferon gamma signaling - Homo sapiens
input	[DefinedSet:R-HSA-9034199] IFNG-regulated genes with GAS promoter elements [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1031686] Transcriptional induction of IFN-gamma-responsive genes is modulated by DNA surrounding the interferon stimulation response element [LiteratureReference:1031678] Induction of guanylate binding protein 5 by gamma interferon increases susceptibility to Salmonella enterica serovar Typhimurium-induced pyroptosis in RAW 264.7 cells [LiteratureReference:1031680] Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3 [LiteratureReference:1031658] Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines [LiteratureReference:1031657] Transcriptional regulation of the human intercellular adhesion molecule-1 gene: a short overview [LiteratureReference:1031647] Cellular responses to interferon-gamma [LiteratureReference:1031674] IFN-gamma up-regulates platelet-activating factor receptor gene expression in human monocytes
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of IFNG-stimulated genes
output	[EntityWithAccessionedSequence:R-HSA-983063] B2M(21-119) [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-1031702] CIITA [nucleoplasm] [DefinedSet:R-HSA-983117] Class I MHC heavy chain (MHC HC) [integral component of lumenal side of endoplasmic reticulum membrane] [DefinedSet:R-HSA-1031694] FCGRA [plasma membrane] [CandidateSet:R-HSA-1031695] GBP [cytosol] [EntityWithAccessionedSequence:R-HSA-1031704] IFI30 [lysosomal lumen] [DefinedSet:R-HSA-1031690] IFN-gamma upregulated CAMs [plasma membrane] [CandidateSet:R-HSA-5624346] IFNG induced TRIMs [cytosol] [DefinedSet:R-HSA-1015695] IRF 1-9 [cytosol] [Complex:R-HSA-2213189] MHC class II alpha/beta dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-1031707] MT2A [cytosol] [DefinedSet:R-HSA-1015696] OAS proteins [cytosol] [EntityWithAccessionedSequence:R-HSA-1031706] PML [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-419376] PTAFR [plasma membrane] [EntityWithAccessionedSequence:R-HSA-1031705] SP100 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-1031713] GAF binds the GAS promoter elements in the IFNG-regulated genes - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-1031722] Positive regulation by 'GAF bound to GAS promoter element [nucleoplasm]'
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1031716
summation	[Summation:1031651] IFN-gamma stimulates gene expression of about 200 genes whic...

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[Pathway:R-HSA-877300] Interferon gamma signaling

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