Reactome | Interferon gamma signaling

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Interferon gamma signaling Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649260
displayName	Interferon gamma signaling
eventOf	[Pathway:R-DRE-913531] Interferon Signaling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:383450] type II interferon-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DRE-873926] IFNG dimer binds IFNGR - Danio rerio [Reaction:R-DRE-9678561] IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors - Danio rerio [Reaction:R-DRE-9689680] IFNG dimer binds IFNG inhibitors - Danio rerio [Reaction:R-DRE-873919] Phosphorylation of JAK2 - Danio rerio [Reaction:R-DRE-873918] Transphosphorylation of JAK1 - Danio rerio [Reaction:R-DRE-873924] Phosphorylation of IFNGR1 by JAK kinases - Danio rerio [BlackBoxEvent:R-DRE-9734547] JAK2-activated MAPKs phosphorylate YBX1 - Danio rerio [BlackBoxEvent:R-DRE-9736836] Phosphorylated YBX1 translocates to the nucleus - Danio rerio [Reaction:R-DRE-873921] Binding of STAT1 to p-IFNGR1 - Danio rerio [Reaction:R-DRE-873922] Phosphorylation of STAT1 by JAK kinases - Danio rerio [Reaction:R-DRE-909552] Phosphorylation of STAT1 at Ser727 - Danio rerio [Reaction:R-DRE-873927] Release of STAT1 dimer from active receptor unit - Danio rerio [BlackBoxEvent:R-DRE-873917] Translocation of STAT1 dimer to nucleus - Danio rerio [Pathway:R-DRE-877312] Regulation of IFNG signaling - Danio rerio [Pathway:R-DRE-9732724] IFNG signaling activates MAPKs - Danio rerio
inferredFrom	[Pathway:R-HSA-877300] Interferon gamma signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Interferon gamma signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-877300
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-913531] Interferon Signaling
(hasEncapsulatedEvent)	[Pathway:R-DRE-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
(inferredTo)	[Pathway:R-HSA-877300] Interferon gamma signaling

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