Reactome | IFNG dimer binds IFNGR

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IFNG dimer binds IFNGR Show undefined attributes

authored	[InstanceEdit:873929] Garapati, P V, 2010-06-08
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:873929] Garapati, P V, 2010-06-08
dbId	873926
displayName	IFNG dimer binds IFNGR
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
eventOf	[Pathway:R-HSA-877300] Interferon gamma signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-873919] Phosphorylation of JAK2 - Homo sapiens
input	[Complex:R-HSA-873823] IFNG dimer [extracellular region] [Complex:R-HSA-873810] IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:873818] Preassembly and ligand-induced restructuring of the chains of the IFN-gamma receptor complex: the roles of Jak kinases, Stat1 and the receptor chains [LiteratureReference:873815] Seeing the light: preassembly and ligand-induced changes of the interferon gamma receptor complex in cells [LiteratureReference:873873] Stoichiometry of interaction between interferon gamma and its receptor [LiteratureReference:873872] Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex [LiteratureReference:873901] Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor [LiteratureReference:873874] Interaction between the components of the interferon gamma receptor complex [LiteratureReference:873864] Identification of an interferon-gamma receptor alpha chain sequence required for JAK-1 binding [LiteratureReference:873876] The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	IFNG dimer binds IFNGR Interaction of IFNG with IFNGR
orthologousEvent	[Reaction:R-GGA-873926] IFNG dimer binds IFNGR - Gallus gallus [Reaction:R-DRE-873926] IFNG dimer binds IFNGR - Danio rerio [Reaction:R-SSC-873926] IFNG dimer binds IFNGR - Sus scrofa [Reaction:R-BTA-873926] IFNG dimer binds IFNGR - Bos taurus [Reaction:R-CFA-873926] IFNG dimer binds IFNGR - Canis familiaris [Reaction:R-RNO-873926] IFNG dimer binds IFNGR - Rattus norvegicus [Reaction:R-MMU-873926] IFNG dimer binds IFNGR - Mus musculus
output	[Complex:R-HSA-873829] IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane]
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-873926
summation	[Summation:873844] The IFNG receptor complex is a pre-assembled entity, as cons...
updateTrackers	[UpdateTracker:9776998] Update Tracker - [Reaction:873926] IFNG dimer binds IFNGR - v73:[addRegulator] [UpdateTracker:9775459] Update Tracker - [Reaction:873926] IFNG dimer binds IFNGR - v79:[removeRegulator] [UpdateTracker:9776710] Update Tracker - [Reaction:873926] IFNG dimer binds IFNGR - v74:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9776998] Update Tracker - [Reaction:873926] IFNG dimer binds IFNGR - v73:[addRegulator] [UpdateTracker:9775459] Update Tracker - [Reaction:873926] IFNG dimer binds IFNGR - v79:[removeRegulator] [UpdateTracker:9776710] Update Tracker - [Reaction:873926] IFNG dimer binds IFNGR - v74:[addRegulator]
(hasEvent)	[Pathway:R-HSA-877300] Interferon gamma signaling
(precedingEvent)	[Reaction:R-HSA-873919] Phosphorylation of JAK2

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