Reactome | Phosphorylation of STAT1 by JAK kinases

Schema > Reaction > Entries

Phosphorylation of STAT1 by JAK kinases Show undefined attributes

authored	[InstanceEdit:873929] Garapati, P V, 2010-06-08
catalystActivity	[CatalystActivity:873928] protein tyrosine kinase activity of STAT1 bound to p-IFNGR1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:873929] Garapati, P V, 2010-06-08
dbId	873922
displayName	Phosphorylation of STAT1 by JAK kinases
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
eventOf	[Pathway:R-HSA-877300] Interferon gamma signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-909552] Phosphorylation of STAT1 at Ser727 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-873828] STAT1 bound to p-IFNGR1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:873892] A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma [LiteratureReference:873904] Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor [LiteratureReference:873845] Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state [LiteratureReference:933486] A road map for those who don't know JAK-STAT
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	Phosphorylation of STAT1 by JAK kinases
orthologousEvent	[Reaction:R-GGA-873922] Phosphorylation of STAT1 by JAK kinases - Gallus gallus [Reaction:R-DRE-873922] Phosphorylation of STAT1 by JAK kinases - Danio rerio [Reaction:R-SSC-873922] Phosphorylation of STAT1 by JAK kinases - Sus scrofa [Reaction:R-BTA-873922] Phosphorylation of STAT1 by JAK kinases - Bos taurus [Reaction:R-CFA-873922] Phosphorylation of STAT1 by JAK kinases - Canis familiaris [Reaction:R-RNO-873922] Phosphorylation of STAT1 by JAK kinases - Rattus norvegicus [Reaction:R-MMU-873922] Phosphorylation of STAT1 by JAK kinases - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-873817] p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-873921] Binding of STAT1 to p-IFNGR1 - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-873922
summation	[Summation:873848] STAT1 pair recruited to the receptor complex is phosphorylat...

Referrals

(hasEvent)	[Pathway:R-HSA-877300] Interferon gamma signaling
(precedingEvent)	[Reaction:R-HSA-909552] Phosphorylation of STAT1 at Ser727