Reactome | GAF binds the GAS promoter elements in the IFNG-regulated genes

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GAF binds the GAS promoter elements in the IFNG-regulated genes Show undefined attributes

authored	[InstanceEdit:909728] Garapati, P V, 2010-07-07
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1031714] Garapati, P V, 2010-11-18
dbId	1031713
displayName	GAF binds the GAS promoter elements in the IFNG-regulated genes
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
eventOf	[Pathway:R-HSA-877300] Interferon gamma signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1031716] Expression of IFNG-stimulated genes - Homo sapiens
input	[DefinedSet:R-HSA-9034199] IFNG-regulated genes with GAS promoter elements [nucleoplasm] [Complex:R-HSA-873824] p-STAT1 homodimer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1031682] Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons [LiteratureReference:1031685] Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor [LiteratureReference:1031676] Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein [LiteratureReference:1031647] Cellular responses to interferon-gamma
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GAF binds the GAS promoter elements in the IFNG-regulated genes
output	[Complex:R-HSA-1031710] GAF bound to GAS promoter element [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-873917] Translocation of STAT1 dimer to nucleus - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1031713
summation	[Summation:1031652] GAF transcription factor translocated into nucleus binds to ...
updateTrackers	[UpdateTracker:9780164] Update Tracker - [Reaction:1031713] GAF binds the GAS promoter elements in the IFNG-regulated genes - v64:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9780164] Update Tracker - [Reaction:1031713] GAF binds the GAS promoter elements in the IFNG-regulated genes - v64:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-877300] Interferon gamma signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-1031716] Expression of IFNG-stimulated genes

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