Reactome | PPA1 hydrolyzes pyrophosphate to orthophosphate

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PPA1 hydrolyzes pyrophosphate to orthophosphate Show undefined attributes

catalystActivity	[CatalystActivity:71731] inorganic diphosphate phosphatase activity of PPA1 dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643920] inorganic diphosphatase activity of PPA1 dimer [cytosol] Studies on human erythrocyte inorganic pyrophosphatase
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12668055] RHEA:24577
dbId	71732
displayName	PPA1 hydrolyzes pyrophosphate to orthophosphate
eventOf	[Pathway:R-HSA-71737] Pyrophosphate hydrolysis - Homo sapiens [Pathway:R-HSA-379716] Cytosolic tRNA aminoacylation - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:71727] Studies on human erythrocyte inorganic pyrophosphatase [LiteratureReference:449925] Purification and some properties of inorganic pyrophosphatase from human erythrocytes [LiteratureReference:449920] Purification and kinetic properties of human erythrocyte Mg2+-dependent inorganic pyrophosphatase
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PPA1 hydrolyzes pyrophosphate to orthophosphate pyrophosphate + H2O => 2 orthophosphate [cytosolic]
orthologousEvent	[Reaction:R-MMU-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Mus musculus [Reaction:R-PFA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Plasmodium falciparum [Reaction:R-SCE-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Saccharomyces cerevisiae [Reaction:R-SPO-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Schizosaccharomyces pombe [Reaction:R-DDI-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Dictyostelium discoideum [Reaction:R-CEL-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Caenorhabditis elegans [Reaction:R-DME-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Drosophila melanogaster [Reaction:R-GGA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Gallus gallus [Reaction:R-XTR-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Xenopus tropicalis [Reaction:R-DRE-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Danio rerio [Reaction:R-SSC-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Sus scrofa [Reaction:R-BTA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Bos taurus [Reaction:R-CFA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Canis familiaris [Reaction:R-RNO-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Rattus norvegicus
output	2 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] - Homo sapiens [Reaction:R-HSA-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Homo sapiens [Reaction:R-HSA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Homo sapiens [Reaction:R-HSA-70286] UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose - Homo sapiens [Reaction:R-HSA-74213] APRT catalyzes the conversion of adenine to AMP - Homo sapiens [Reaction:R-HSA-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Homo sapiens [Reaction:R-HSA-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Homo sapiens [Reaction:R-HSA-2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - Homo sapiens [Reaction:R-HSA-2395818] NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP - Homo sapiens [Reaction:R-HSA-9731228] NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP - Homo sapiens [Reaction:R-HSA-9731613] NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP - Homo sapiens [Reaction:R-HSA-9731632] NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP - Homo sapiens [Reaction:R-HSA-9731590] NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP - Homo sapiens [Reaction:R-HSA-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Homo sapiens [Reaction:R-HSA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Homo sapiens [Reaction:R-HSA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Homo sapiens
regulatedBy	[Requirement:R-HSA-449940] Requirement by 'Mg2+ [cytosol]'
regulationReference	[RegulationReference:9641612] Requirement by 'Mg2+ [cytosol]' Purification and kinetic properties of human erythrocyte Mg2+-dependent inorganic pyrophosphatase
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:449926] D'Eustachio, P, 2009-12-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71732
summation	[Summation:179126] Cytosolic PPA1 (pyrophosphatase (inorganic) 1) catalyzes the...
updateTrackers	[UpdateTracker:9791012] Update Tracker - [Reaction:71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - v32:[addLiteratureReference, addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791012] Update Tracker - [Reaction:71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - v32:[addLiteratureReference, addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-379716] Cytosolic tRNA aminoacylation [Pathway:R-HSA-71737] Pyrophosphate hydrolysis

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