Reactome | ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA

Schema > Reaction > Entries

ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA Show undefined attributes

authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:70576] argininosuccinate synthase activity of ASS1 tetramer:NMRAL1 dimer:NADPH [cytosol]
catalystActivityReference	[CatalystActivityReference:9643595] argininosuccinate synthase activity of ASS1 tetramer:NMRAL1 dimer:NADPH [cytosol] Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667669] RHEA:10933
dbId	70577
diseaseReaction	[FailedReaction:R-HSA-9956517] ASS1 variants don't synthesize arginosuccinate - Homo sapiens
displayName	ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
eventOf	[Pathway:R-HSA-70635] Urea cycle - Homo sapiens
followingEvent	[Reaction:R-HSA-70573] argininosuccinate <=> fumarate + arginine - Homo sapiens [Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29448] L-Asp [cytosol] [SimpleEntity:R-ALL-29968] L-Cit [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:451985] Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene [LiteratureReference:451992] Structure of human argininosuccinate synthetase [LiteratureReference:74567] Isolation and characterization of argininosuccinate synthetase from human liver [LiteratureReference:6810885] Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein [LiteratureReference:6810872] An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate
orthologousEvent	[Reaction:R-MMU-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Mus musculus [Reaction:R-GGA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Gallus gallus [Reaction:R-CFA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Canis familiaris [Reaction:R-XTR-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Xenopus tropicalis [Reaction:R-SSC-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Sus scrofa [Reaction:R-BTA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Bos taurus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-34575] ARSUA [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Homo sapiens [Reaction:R-HSA-70581] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:452018] D'Eustachio, P, 2010-01-14 [InstanceEdit:6810886] Jassal, Bijay, 2015-11-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70577
summation	[Summation:178493] Cytosolic argininosuccinate synthase (ASS1 tetramer) catalyz...
updateTrackers	[UpdateTracker:9789598] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v37:[modifyText] [UpdateTracker:9783430] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v56:[addLiteratureReference, modifyText] [UpdateTracker:9791236] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v32:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789598] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v37:[modifyText] [UpdateTracker:9783430] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v56:[addLiteratureReference, modifyText] [UpdateTracker:9791236] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v32:[add_removeLiteratureReference, modifyText]
(normalReaction)	[FailedReaction:R-HSA-9956517] ASS1 variants don't synthesize arginosuccinate
(precedingEvent)	[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Reaction:R-HSA-70573] argininosuccinate <=> fumarate + arginine
(hasEvent)	[Pathway:R-HSA-70635] Urea cycle

Cite Us!