Reactome | 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate

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5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate Show undefined attributes

authored	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
catalystActivity	[CatalystActivity:73791] amidophosphoribosyltransferase activity of PPAT dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
crossReference	[DatabaseIdentifier:12667772] RHEA:14907 [DatabaseIdentifier:9975677] RHEA:14907
dbId	73815
displayName	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate
edited	[InstanceEdit:165090] Jassal, B, D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-73817] Purine ribonucleoside monophosphate biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-73814] 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi - Homo sapiens [Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29472] L-Gln [cytosol] [SimpleEntity:R-ALL-73566] PRPP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111230] Human glutamine phosphoribosylpyrophosphate amidotransferase. Kinetic and regulatory properties [LiteratureReference:111231] Human glutamine phosphoribosylpyrophosphate amidotransferase. Two molecular forms interconvertible by purine ribonucleotides and phosphoribosylpyrophosphate [LiteratureReference:111232] Human amidophosphoribosyltransferase. An oxygen-sensitive iron-sulfur protein [LiteratureReference:111233] Molecular cloning of human amidophosphoribosyltransferase [LiteratureReference:419266] Reversible compartmentalization of de novo purine biosynthetic complexes in living cells
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O => 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate PRPP + H2O + L-Glutamine => 5-Phosphoribosylamine + L-Glutamate + PPi
orthologousEvent	[Reaction:R-GGA-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Gallus gallus [Reaction:R-SSC-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Sus scrofa [Reaction:R-CEL-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Caenorhabditis elegans [Reaction:R-DME-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Drosophila melanogaster [Reaction:R-XTR-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Xenopus tropicalis [Reaction:R-DRE-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Danio rerio [Reaction:R-BTA-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Bos taurus [Reaction:R-CFA-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Canis familiaris [Reaction:R-RNO-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Rattus norvegicus [Reaction:R-MMU-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Mus musculus
output	[SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol] [SimpleEntity:R-ALL-111292] PRA [cytosol]
precedingEvent	[Reaction:R-HSA-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Homo sapiens [Reaction:R-HSA-73580] PRPS dimers pyrophosphorylate R5P using ATP - Homo sapiens [Reaction:R-HSA-111289] Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73815
summation	[Summation:73819] Cytosolic PPAT (phosphoribosyl pyrophosphate amidotransferas...
updateTrackers	[UpdateTracker:9791519] Update Tracker - [Reaction:73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - v29:[addLiteratureReference, modifyText] [UpdateTracker:9786602] Update Tracker - [Reaction:73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - v49:[removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9791519] Update Tracker - [Reaction:73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - v29:[addLiteratureReference, modifyText] [UpdateTracker:9786602] Update Tracker - [Reaction:73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - v49:[removeRegulator]
(precedingEvent)	[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Reaction:R-HSA-73814] 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi
(hasEvent)	[Pathway:R-HSA-73817] Purine ribonucleoside monophosphate biosynthesis

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