Reactome | Cytosolic tRNA aminoacylation

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Cytosolic tRNA aminoacylation Show undefined attributes

authored	[InstanceEdit:386989] D'Eustachio, P, 2008-11-29 15:41:00
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:379702] D'Eustachio, P, 2008-11-04 23:29:06
dbId	379716
displayName	Cytosolic tRNA aminoacylation
edited	[InstanceEdit:386989] D'Eustachio, P, 2008-11-29 15:41:00
eventOf	[Pathway:R-HSA-379724] tRNA Aminoacylation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18542] tRNA aminoacylation for protein translation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-379864] alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379993] arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379996] asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379867] aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379887] cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379861] glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379982] glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-380048] glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379844] histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379893] isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379974] leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-380008] lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379994] methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379848] phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379865] proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379992] serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-380002] threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379977] tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379980] tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-380042] valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:380805] Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein [LiteratureReference:379614] Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII [LiteratureReference:380813] A three-dimensional working model of the multienzyme complex of aminoacyl-tRNA synthetases based on electron microscopic placements of tRNA and proteins
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Cytosolic tRNA aminoacylation
orthologousEvent	[Pathway:R-MMU-379716] Cytosolic tRNA aminoacylation - Mus musculus [Pathway:R-RNO-379716] Cytosolic tRNA aminoacylation - Rattus norvegicus [Pathway:R-CFA-379716] Cytosolic tRNA aminoacylation - Canis familiaris [Pathway:R-BTA-379716] Cytosolic tRNA aminoacylation - Bos taurus [Pathway:R-SSC-379716] Cytosolic tRNA aminoacylation - Sus scrofa [Pathway:R-DRE-379716] Cytosolic tRNA aminoacylation - Danio rerio [Pathway:R-XTR-379716] Cytosolic tRNA aminoacylation - Xenopus tropicalis [Pathway:R-GGA-379716] Cytosolic tRNA aminoacylation - Gallus gallus [Pathway:R-DME-379716] Cytosolic tRNA aminoacylation - Drosophila melanogaster [Pathway:R-CEL-379716] Cytosolic tRNA aminoacylation - Caenorhabditis elegans [Pathway:R-DDI-379716] Cytosolic tRNA aminoacylation - Dictyostelium discoideum [Pathway:R-SPO-379716] Cytosolic tRNA aminoacylation - Schizosaccharomyces pombe [Pathway:R-SCE-379716] Cytosolic tRNA aminoacylation - Saccharomyces cerevisiae [Pathway:R-PFA-379716] Cytosolic tRNA aminoacylation - Plasmodium falciparum
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387428] Antonellis, A, 2008-12-02 16:58:45
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-379716
summation	[Summation:379696] Cytosolic tRNA synthetases catalyze the reactions of tRNAs e...
updateTrackers	[UpdateTracker:9789293] Update Tracker - [Pathway:379716] Cytosolic tRNA aminoacylation - v38:[addLiteratureReference] [UpdateTracker:9789595] Update Tracker - [Pathway:379716] Cytosolic tRNA aminoacylation - v37:[updateContainedRLE] [UpdateTracker:9790341] Update Tracker - [Pathway:379716] Cytosolic tRNA aminoacylation - v33:[addHasEvent, updateContainedRLE] [UpdateTracker:9791565] Update Tracker - [Pathway:379716] Cytosolic tRNA aminoacylation - v28:[updateContainedRLE] [UpdateTracker:9782160] Update Tracker - [Pathway:379716] Cytosolic tRNA aminoacylation - v59:[updateContainedRLE]

Referrals

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[Pathway:R-HSA-379724] tRNA Aminoacylation

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