Reactome | UMPS dimer transfers phosphoribosyl group to ORO to form OMP

Schema > Reaction > Entries

UMPS dimer transfers phosphoribosyl group to ORO to form OMP Show undefined attributes

authored	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
catalystActivity	[CatalystActivity:73491] orotate phosphoribosyltransferase activity of UMPS dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:12668046] RHEA:10382 [DatabaseIdentifier:9975778] RHEA:10382
dbId	73567
displayName	UMPS dimer transfers phosphoribosyl group to ORO to form OMP
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-500753] Pyrimidine biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-73564] UMPS dimer decarboxylates OMP to UMP - Homo sapiens [Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-76632] ORO [cytosol] [SimpleEntity:R-ALL-73566] PRPP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111648] Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families [LiteratureReference:419511] Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase [LiteratureReference:111659] Isolation and initial characterization of the single polypeptide that synthesizes uridine 5'-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'-monophosphate synthase [LiteratureReference:419510] Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	UMPS dimer transfers phosphoribosyl group to ORO to form OMP orotate + 5-phospho-alpha-D-ribose 1-diphosphate => orotidine 5'-phosphate + diphosphate orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate phosphoribosylation of orotate to form oritidine 5'-phosphate (OMP)
orthologousEvent	[Reaction:R-GGA-419462] orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate - Gallus gallus [Reaction:R-MMU-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Mus musculus [Reaction:R-DDI-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Dictyostelium discoideum [Reaction:R-CEL-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Caenorhabditis elegans [Reaction:R-DME-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Drosophila melanogaster [Reaction:R-GGA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Gallus gallus [Reaction:R-XTR-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Xenopus tropicalis [Reaction:R-DRE-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Danio rerio [Reaction:R-SSC-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Sus scrofa [Reaction:R-BTA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Bos taurus [Reaction:R-CFA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Canis familiaris [Reaction:R-RNO-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Rattus norvegicus
output	[SimpleEntity:R-ALL-111629] OMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-73569] DHODH:FMN oxidises (S)-DHO to orotate - Homo sapiens [Reaction:R-HSA-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Homo sapiens [Reaction:R-HSA-73580] PRPS dimers pyrophosphorylate R5P using ATP - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73567
summation	[Summation:111658] The synthesis of orotidine 5'-monophosphate (OMP) from orota...
updateTrackers	[UpdateTracker:9791501] Update Tracker - [Reaction:73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - v29:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791501] Update Tracker - [Reaction:73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - v29:[addLiteratureReference, modifyText]
(precedingEvent)	[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Reaction:R-HSA-73564] UMPS dimer decarboxylates OMP to UMP
(hasEvent)	[Pathway:R-HSA-500753] Pyrimidine biosynthesis