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Entries
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP
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authored
[InstanceEdit:2395962] D'Eustachio, P, 2012-07-06
catalystActivity
[CatalystActivity:2395832] 2-hydroxy-ATP hydrolase activity of NUDT1 [cytosol]
catalystActivityReference
[CatalystActivityReference:9643728] 2-hydroxy-ATP hydrolase activity of NUDT1 [cytosol] The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:2395885] D'Eustachio, P, 2012-07-03
crossReference
[DatabaseIdentifier:12667785] RHEA:67393
[DatabaseIdentifier:9976352] RHEA:67393
dbId
2395872
displayName
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP
edited
[InstanceEdit:2395962] D'Eustachio, P, 2012-07-06
eventOf
[Pathway:R-HSA-2393930] Phosphate bond hydrolysis by NUDT proteins - Homo sapiens
followingEvent
[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Homo sapiens
input
[SimpleEntity:R-ALL-9731240] 2-oxo-ATP(4-) [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:2395886] Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP
[LiteratureReference:1418849] Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria
[LiteratureReference:2395806] Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP
2-oxo-ATP + H2O => 2-oxo-AMP + diphosphate + H(+)
orthologousEvent
[Reaction:R-GGA-2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - Gallus gallus
[Reaction:R-XTR-2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - Xenopus tropicalis
[Reaction:R-DRE-2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - Danio rerio
[Reaction:R-SSC-2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - Sus scrofa
[Reaction:R-BTA-2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - Bos taurus
[Reaction:R-CFA-2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - Canis familiaris
[Reaction:R-RNO-2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - Rattus norvegicus
[Reaction:R-MMU-2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - Mus musculus
output
[SimpleEntity:R-ALL-9731231] 2-oxo-AMP(2-) [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate
2012-12-04
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2509804] Ito, Riyoko, 2012-10-05
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2395872
summation
[Summation:2395871] NUDT1 (MTH1) catalyzes the reaction of 2-oxo-ATP and water t...
updateTrackers
[UpdateTracker:9775958] Update Tracker - [Reaction:2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - v78:[add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9776087] Update Tracker - [Reaction:2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - v77:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9775958] Update Tracker - [Reaction:2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - v78:[add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9776087] Update Tracker - [Reaction:2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - v77:[modifyText]
(precedingEvent)
[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate
(hasEvent)
[Pathway:R-HSA-2393930] Phosphate bond hydrolysis by NUDT proteins
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