Reactome | HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP

Schema > Reaction > Entries

HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP Show undefined attributes

catalystActivity	[CatalystActivity:74210] purine phosphoribosyltransferase activity of HPRT1 tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643820] purine phosphoribosyltransferase activity of HPRT1 tetramer [cytosol] Human hypoxanthine-guanine phosphoribosyltransferase. Evidence for tetrameric structure
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
crossReference	[DatabaseIdentifier:9976248] RHEA:25426 [DatabaseIdentifier:9976246] RHEA:17975
dbId	74215
deleted	[Deleted:500264] Deletion of instance: 73823
diseaseReaction	[FailedReaction:R-HSA-9734274] Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP - Homo sapiens
displayName	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP
eventOf	[Pathway:R-HSA-74217] Purine salvage - Homo sapiens
followingEvent	[Reaction:R-HSA-514604] GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Homo sapiens [Reaction:R-HSA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Homo sapiens [Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Homo sapiens
input	[DefinedSet:R-ALL-500259] Gua, Hyp [cytosol] [SimpleEntity:R-ALL-73566] PRPP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200106] Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1) guanine + 5-phospho-alpha-D-ribose 1-diphosphate => GMP + diphosphate hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate => IMP + diphosphate
orthologousEvent	[Reaction:R-PFA-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Plasmodium falciparum [Reaction:R-DDI-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Dictyostelium discoideum [Reaction:R-CEL-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Caenorhabditis elegans [Reaction:R-GGA-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Gallus gallus [Reaction:R-DRE-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Danio rerio [Reaction:R-SSC-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Sus scrofa [Reaction:R-BTA-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Bos taurus [Reaction:R-CFA-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Canis familiaris [Reaction:R-RNO-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Rattus norvegicus [Reaction:R-MMU-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Mus musculus
output	[DefinedSet:R-ALL-500260] GMP, IMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-74215
summation	[Summation:178835] Cytosolic hypoxanthine-guanine phosphoribosyltransferase (HP...
updateTrackers	[UpdateTracker:9792279] Update Tracker - [Reaction:74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - v22:[addLiteratureReference] [UpdateTracker:9791208] Update Tracker - [Reaction:74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - v32:[add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9792279] Update Tracker - [Reaction:74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - v22:[addLiteratureReference] [UpdateTracker:9791208] Update Tracker - [Reaction:74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - v32:[add_removeInput, add_removeOutput, modifyText]
(replacementInstances)	[Deleted:500264] Deletion of instance: 73823
(precedingEvent)	[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Reaction:R-HSA-514604] GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) [Reaction:R-HSA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)
(hasEvent)	[Pathway:R-HSA-74217] Purine salvage
(normalReaction)	[FailedReaction:R-HSA-9734274] Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP