Reactome | PPA1 hydrolyzes pyrophosphate to orthophosphate

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PPA1 hydrolyzes pyrophosphate to orthophosphate Show undefined attributes

catalystActivity	[CatalystActivity:10903190] inorganic diphosphatase activity of PPA1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
dbId	10903192
displayName	PPA1 hydrolyzes pyrophosphate to orthophosphate
eventOf	[Pathway:R-SCE-379716] Cytosolic tRNA aminoacylation - Saccharomyces cerevisiae [Pathway:R-SCE-71737] Pyrophosphate hydrolysis - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
isInDisease	false
isInferred	true
name	PPA1 hydrolyzes pyrophosphate to orthophosphate pyrophosphate + H2O => 2 orthophosphate [cytosolic]
output	2 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-SCE-70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] - Saccharomyces cerevisiae [Reaction:R-SCE-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Saccharomyces cerevisiae [Reaction:R-SCE-70286] UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose - Saccharomyces cerevisiae [Reaction:R-SCE-74213] APRT catalyzes the conversion of adenine to AMP - Saccharomyces cerevisiae [Reaction:R-SCE-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Saccharomyces cerevisiae [Reaction:R-SCE-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Saccharomyces cerevisiae
regulatedBy	[Requirement:R-GGA-352997] Requirement by 'Mg2+ [cytosol]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-71732
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-379716] Cytosolic tRNA aminoacylation [Pathway:R-SCE-71737] Pyrophosphate hydrolysis
(inferredTo)	[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate