Reactome | acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]

Schema > Reaction > Entries

acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] Show undefined attributes

authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:71734] acetate-CoA ligase activity of ACSS2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:11881049] Rhea:23177
dbId	71735
displayName	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]
eventOf	[Pathway:R-HSA-71384] Ethanol oxidation - Homo sapiens
followingEvent	[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29416] CH3COO- [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:71683] Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins.
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]
orthologousEvent	[Reaction:R-PFA-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Plasmodium falciparum [Reaction:R-SCE-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Saccharomyces cerevisiae [Reaction:R-SPO-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Schizosaccharomyces pombe [Reaction:R-DDI-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Dictyostelium discoideum [Reaction:R-CEL-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Caenorhabditis elegans [Reaction:R-DME-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Drosophila melanogaster [Reaction:R-GGA-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Gallus gallus [Reaction:R-XTR-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Xenopus tropicalis [Reaction:R-SSC-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Sus scrofa [Reaction:R-BTA-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Bos taurus [Reaction:R-CFA-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Canis familiaris [Reaction:R-RNO-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Rattus norvegicus [Reaction:R-MMU-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Mus musculus
output	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-71691] acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] - Homo sapiens
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:449910] D'Eustachio, P, 2009-12-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71735
summation	[Summation:71736] Cytosolic ACSS2 (acetyl-coenzyme A synthetase) catalyzes the...

Referrals

(hasEvent)	[Pathway:R-HSA-71384] Ethanol oxidation
(precedingEvent)	[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate