Reactome | PPA1 hydrolyzes pyrophosphate to orthophosphate

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PPA1 hydrolyzes pyrophosphate to orthophosphate Show undefined attributes

catalystActivity	[CatalystActivity:10562310] inorganic diphosphate phosphatase activity of PPA1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10562312
displayName	PPA1 hydrolyzes pyrophosphate to orthophosphate
eventOf	[Pathway:R-DRE-379716] Cytosolic tRNA aminoacylation - Danio rerio [Pathway:R-DRE-71737] Pyrophosphate hydrolysis - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PPA1 hydrolyzes pyrophosphate to orthophosphate pyrophosphate + H2O => 2 orthophosphate [cytosolic]
output	2 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-DRE-70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] - Danio rerio [Reaction:R-DRE-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Danio rerio [Reaction:R-DRE-74213] APRT catalyzes the conversion of adenine to AMP - Danio rerio [Reaction:R-DRE-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Danio rerio [Reaction:R-DRE-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Danio rerio [Reaction:R-DRE-2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - Danio rerio [Reaction:R-DRE-2395818] NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP - Danio rerio [Reaction:R-DRE-9731228] NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP - Danio rerio [Reaction:R-DRE-9731613] NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP - Danio rerio [Reaction:R-DRE-9731632] NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP - Danio rerio [Reaction:R-DRE-9731590] NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP - Danio rerio [Reaction:R-DRE-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Danio rerio [Reaction:R-DRE-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Danio rerio [Reaction:R-DRE-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Danio rerio
regulatedBy	[Requirement:R-HSA-2509853] Requirement by 'Mg2+ [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-71732
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-379716] Cytosolic tRNA aminoacylation [Pathway:R-DRE-71737] Pyrophosphate hydrolysis
(inferredTo)	[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate

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