Reactome | OGDH dimer decarboxylates 2-OG

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OGDH dimer decarboxylates 2-OG Show undefined attributes

authored	[InstanceEdit:9855937] Stephan, Ralf, 2023-12-08
catalystActivity	[CatalystActivity:9859269] oxoglutarate dehydrogenase (succinyl-transferring) activity of OGDH complex [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9853514] RHEA:12189
dbId	71401
deleted	[Deleted:451021] Deletion of instances: 71036, 70961, 70960, 70959, 70957
displayName	OGDH dimer decarboxylates 2-OG
eventOf	[Pathway:R-HSA-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Homo sapiens
followingEvent	[Reaction:R-HSA-70997] SUCLG1/A2 cleaves succinyl-CoA - Homo sapiens [Reaction:R-HSA-9853512] DLST transfers succinyl to CoA - Homo sapiens [Reaction:R-HSA-71775] SUCLG1/G2 cleaves succinyl-CoA - Homo sapiens [Reaction:R-HSA-1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) - Homo sapiens [Reaction:R-HSA-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Homo sapiens [Reaction:R-HSA-1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria) - Homo sapiens [Reaction:R-HSA-1237047] CA4:Zn2+ hydrates CO2 to HCO3- - Homo sapiens [Reaction:R-HSA-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-1237069] RHAG transports CO2 from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-69993] Lipo-K110-DLST [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9853513] Structural basis for the activity and regulation of human ?-ketoglutarate dehydrogenase revealed by Cryo-EM [LiteratureReference:9853687] The human Krebs cycle 2-oxoglutarate dehydrogenase complex creates an additional source of superoxide/hydrogen peroxide from 2-oxoadipate as alternative substrate [LiteratureReference:9853670] Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate [LiteratureReference:9853675] Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	OGDH dimer decarboxylates 2-OG 2-oxoglutarate + H(+) + N(6)-((R)-lipoyl)-L-lysyl-(dihydrolipoyllysine-residue succinyltransferase) => CO2 + N(6)-((R)-S(8)-succinyldihydrolipoyl)-L-lysyl-(dihydrolipoyllysine-residue succinyltransferase) Oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA by alpha-ketoglutarate dehydrogenase
orthologousEvent	[Reaction:R-GGA-373042] 2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+ - Gallus gallus [Reaction:R-MMU-71401] OGDH dimer decarboxylates 2-OG - Mus musculus [Reaction:R-XTR-71401] OGDH dimer decarboxylates 2-OG - Xenopus tropicalis [Reaction:R-CEL-71401] OGDH dimer decarboxylates 2-OG - Caenorhabditis elegans [Reaction:R-DDI-71401] OGDH dimer decarboxylates 2-OG - Dictyostelium discoideum [Reaction:R-GGA-71401] OGDH dimer decarboxylates 2-OG - Gallus gallus [Reaction:R-SPO-71401] OGDH dimer decarboxylates 2-OG - Schizosaccharomyces pombe [Reaction:R-SCE-71401] OGDH dimer decarboxylates 2-OG - Saccharomyces cerevisiae [Reaction:R-PFA-71401] OGDH dimer decarboxylates 2-OG - Plasmodium falciparum [Reaction:R-SSC-71401] OGDH dimer decarboxylates 2-OG - Sus scrofa [Reaction:R-DME-71401] OGDH dimer decarboxylates 2-OG - Drosophila melanogaster [Reaction:R-DRE-71401] OGDH dimer decarboxylates 2-OG - Danio rerio [Reaction:R-BTA-71401] OGDH dimer decarboxylates 2-OG - Bos taurus [Reaction:R-CFA-71401] OGDH dimer decarboxylates 2-OG - Canis familiaris [Reaction:R-RNO-71401] OGDH dimer decarboxylates 2-OG - Rattus norvegicus
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-9853502] SuccinyllipoH2-K110-DLST [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70967] IDH3 complex decarboxylates isocitrate - Homo sapiens [Reaction:R-HSA-9853499] DLD dimer dehydrogenates dihydrolipoyl - Homo sapiens [Reaction:R-HSA-450984] IDH2 dimer decarboxylates isocitrate - Homo sapiens [Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL - Homo sapiens [Reaction:R-HSA-450971] NNT dimer transfers proton from NADPH to NAD+ - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:9853661] Positive regulation by 'NADH [mitochondrial matrix]' [PositiveRegulation:9853679] Positive regulation by 'ATP [mitochondrial matrix]' [NegativeRegulation:9853693] Negative regulation by 'Ca2+ [mitochondrial matrix]' [NegativeRegulation:9853662] Negative regulation by 'ADP [mitochondrial matrix]'
regulationReference	[RegulationReference:9853680] Positive regulation by 'NADH [mitochondrial matrix]' Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site [RegulationReference:9853673] Positive regulation by 'ATP [mitochondrial matrix]' Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site [RegulationReference:9853689] Negative regulation by 'Ca2+ [mitochondrial matrix]' Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site [RegulationReference:9853674] Negative regulation by 'ADP [mitochondrial matrix]' Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
revised	[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71401
summation	[Summation:9853750] 2-Oxoglutarate dehydrogenase complex (OGDHC) component E1 (O...
updateTrackers	[UpdateTracker:9788733] Update Tracker - [Reaction:71401] alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ - v40:[modifyText, removeOutput] [UpdateTracker:9864014] Update Tracker - [Reaction:71401] OGDH dimer decarboxylates 2-OG - v88:[addRegulator, add_removeCatalystActivity, add_removeInput, add_removeLiteratureReference, add_removeOutput, add_removeSummation]

Referrals

(precedingEvent)	[Reaction:R-HSA-1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) [Reaction:R-HSA-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) [Reaction:R-HSA-1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria) [Reaction:R-HSA-1237047] CA4:Zn2+ hydrates CO2 to HCO3- [Reaction:R-HSA-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol [Reaction:R-HSA-1237069] RHAG transports CO2 from extracellular region to cytosol [Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-HSA-70997] SUCLG1/A2 cleaves succinyl-CoA [Reaction:R-HSA-9853512] DLST transfers succinyl to CoA [Reaction:R-HSA-71775] SUCLG1/G2 cleaves succinyl-CoA
(hasEvent)	[Pathway:R-HSA-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG
(replacementInstances)	[Deleted:451021] Deletion of instances: 71036, 70961, 70960, 70959, 70957
(updatedInstance)	[UpdateTracker:9788733] Update Tracker - [Reaction:71401] alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ - v40:[modifyText, removeOutput] [UpdateTracker:9864014] Update Tracker - [Reaction:71401] OGDH dimer decarboxylates 2-OG - v88:[addRegulator, add_removeCatalystActivity, add_removeInput, add_removeLiteratureReference, add_removeOutput, add_removeSummation]

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