Reactome | IDH2 dimer decarboxylates isocitrate

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IDH2 dimer decarboxylates isocitrate Show undefined attributes

authored	[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
catalystActivity	[CatalystActivity:450976] isocitrate dehydrogenase (NADP+) activity of IDH2 dimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643209] isocitrate dehydrogenase (NADP+) activity of IDH2 dimer [mitochondrial matrix] Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:450991] D'Eustachio, P, 2009-12-24
crossReference	[DatabaseIdentifier:9854181] RHEA:19629 [DatabaseIdentifier:11880515] Rhea:19630
dbId	450984
displayName	IDH2 dimer decarboxylates isocitrate
eventOf	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle) - Homo sapiens
followingEvent	[Reaction:R-HSA-450971] NNT dimer transfers proton from NADPH to NAD+ - Homo sapiens [Reaction:R-HSA-1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) - Homo sapiens [Reaction:R-HSA-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Homo sapiens [Reaction:R-HSA-1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria) - Homo sapiens [Reaction:R-HSA-1237047] CA4:Zn2+ hydrates CO2 to HCO3- - Homo sapiens [Reaction:R-HSA-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-1237069] RHAG transports CO2 from extracellular region to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-29938] ISCIT [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:451000] Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism [LiteratureReference:450998] Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle [LiteratureReference:450968] Di- and triphosphopyridine nucleotide isocitric dehydrogenases in yeast [LiteratureReference:450970] Biosynthesis of tricarboxylic acids by carbon dioxide fixation; enzymatic mechanisms [LiteratureReference:9853650] Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase [LiteratureReference:9853642] IDH2 mutations in patients with D-2-hydroxyglutaric aciduria
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	IDH2 dimer decarboxylates isocitrate D-threo-isocitrate + NADP(+) => 2-oxoglutarate + CO2 + NADPH
orthologousEvent	[Reaction:R-PFA-450984] IDH2 dimer decarboxylates isocitrate - Plasmodium falciparum [Reaction:R-CEL-450984] IDH2 dimer decarboxylates isocitrate - Caenorhabditis elegans [Reaction:R-GGA-450984] IDH2 dimer decarboxylates isocitrate - Gallus gallus [Reaction:R-XTR-450984] IDH2 dimer decarboxylates isocitrate - Xenopus tropicalis [Reaction:R-DRE-450984] IDH2 dimer decarboxylates isocitrate - Danio rerio [Reaction:R-SSC-450984] IDH2 dimer decarboxylates isocitrate - Sus scrofa [Reaction:R-BTA-450984] IDH2 dimer decarboxylates isocitrate - Bos taurus [Reaction:R-CFA-450984] IDH2 dimer decarboxylates isocitrate - Canis familiaris [Reaction:R-RNO-450984] IDH2 dimer decarboxylates isocitrate - Rattus norvegicus [Reaction:R-MMU-450984] IDH2 dimer decarboxylates isocitrate - Mus musculus
output	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70971] ACO2 isomerizes citrate - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[NegativeRegulation:9855774] Negative regulation by 'AcK-IDH2 dimer [mitochondrial matrix]'
regulationReference	[RegulationReference:9855773] Negative regulation by 'AcK-IDH2 dimer [mitochondrial matrix]' Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-450984
summation	[Summation:450992] Mitochondrial isocitrate dehydrogenase IDH2 catalyzes the ir...

Referrals

(precedingEvent)

(hasEvent)

[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle)

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