Reactome | DLST transfers succinyl to CoA

Schema > Reaction > Entries

DLST transfers succinyl to CoA Show undefined attributes

authored	[InstanceEdit:9853489] Stephan, Ralf, 2023-11-05
catalystActivity	[CatalystActivity:9853498] dihydrolipoyllysine-residue succinyltransferase activity of OGDH complex [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9853494] Stephan, Ralf, 2023-11-16
crossReference	[DatabaseIdentifier:9853769] RHEA:15215
dbId	9853512
displayName	DLST transfers succinyl to CoA
edited	[InstanceEdit:9859598] Stephan, Ralf, 2024-01-22
eventOf	[Pathway:R-HSA-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Homo sapiens
followingEvent	[Reaction:R-HSA-9853499] DLD dimer dehydrogenates dihydrolipoyl - Homo sapiens
input	[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-9853502] SuccinyllipoH2-K110-DLST [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9853743] Structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate dehydrogenase complex (hKGDHc) revealed by cryo-EM and cross-linking mass spectrometry: Implications for the overall hKGDHc structure [LiteratureReference:9853756] Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas [LiteratureReference:9853979] Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	DLST transfers succinyl to CoA (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-(2-oxoglutarate dehydrogenase complex component E2) + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-(2-oxoglutarate dehydrogenase complex component E2) + succinyl-CoA
negativePrecedingEvent	[NegativePrecedingEvent:9908924] Futile Cycle: SUCLG1/A2 cleaves succinyl-CoA [NegativePrecedingEvent:9908915] Futile Cycle: SUCLG1/G2 cleaves succinyl-CoA
orthologousEvent	[Reaction:R-DME-9853512] DLST transfers succinyl to CoA - Drosophila melanogaster [Reaction:R-SSC-9853512] DLST transfers succinyl to CoA - Sus scrofa [Reaction:R-PFA-9853512] DLST transfers succinyl to CoA - Plasmodium falciparum [Reaction:R-SCE-9853512] DLST transfers succinyl to CoA - Saccharomyces cerevisiae [Reaction:R-SPO-9853512] DLST transfers succinyl to CoA - Schizosaccharomyces pombe [Reaction:R-GGA-9853512] DLST transfers succinyl to CoA - Gallus gallus [Reaction:R-DDI-9853512] DLST transfers succinyl to CoA - Dictyostelium discoideum [Reaction:R-CEL-9853512] DLST transfers succinyl to CoA - Caenorhabditis elegans [Reaction:R-XTR-9853512] DLST transfers succinyl to CoA - Xenopus tropicalis [Reaction:R-DRE-9853512] DLST transfers succinyl to CoA - Danio rerio [Reaction:R-BTA-9853512] DLST transfers succinyl to CoA - Bos taurus [Reaction:R-CFA-9853512] DLST transfers succinyl to CoA - Canis familiaris [Reaction:R-RNO-9853512] DLST transfers succinyl to CoA - Rattus norvegicus [Reaction:R-MMU-9853512] DLST transfers succinyl to CoA - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-9853485] LipoH2-K110-DLST [mitochondrial matrix] [SimpleEntity:R-ALL-70958] SUCC-CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-71401] OGDH dimer decarboxylates 2-OG - Homo sapiens [Reaction:R-HSA-70975] CS acetylates OA to citrate - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9853512
summation	[Summation:9853764] Dihydrolipoyl succinyl transferase (DLST), the E2 component ...

Referrals

(hasEvent)	[Pathway:R-HSA-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG
(precedingEvent)	[NegativePrecedingEvent:9908922] Futile Cycle: DLST transfers succinyl to CoA [NegativePrecedingEvent:9908914] Futile Cycle: DLST transfers succinyl to CoA [Reaction:R-HSA-9853499] DLD dimer dehydrogenates dihydrolipoyl