Reactome | OGDH dimer decarboxylates 2-OG

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OGDH dimer decarboxylates 2-OG Show undefined attributes

catalystActivity	[CatalystActivity:10734401] oxoglutarate dehydrogenase (succinyl-transferring) activity of OGDH complex [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10734403
displayName	OGDH dimer decarboxylates 2-OG
eventOf	[Pathway:R-GGA-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-9853512] DLST transfers succinyl to CoA - Gallus gallus [Reaction:R-GGA-71775] SUCLG1/G2 cleaves succinyl-CoA - Gallus gallus [Reaction:R-GGA-70997] SUCLG1/A2 cleaves succinyl-CoA - Gallus gallus [Reaction:R-GGA-1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) - Gallus gallus [Reaction:R-GGA-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Gallus gallus [Reaction:R-GGA-1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria) - Gallus gallus [Reaction:R-GGA-1237047] CA4:Zn2+ hydrates CO2 to HCO3- - Gallus gallus [Reaction:R-GGA-1237069] RHAG transports CO2 from extracellular region to cytosol - Gallus gallus [Reaction:R-GGA-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol - Gallus gallus [Reaction:R-GGA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Gallus gallus
inferredFrom	[Reaction:R-HSA-71401] OGDH dimer decarboxylates 2-OG - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [EntityWithAccessionedSequence:R-GGA-69993] DLST [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	OGDH dimer decarboxylates 2-OG 2-oxoglutarate + H(+) + N(6)-((R)-lipoyl)-L-lysyl-(dihydrolipoyllysine-residue succinyltransferase) => CO2 + N(6)-((R)-S(8)-succinyldihydrolipoyl)-L-lysyl-(dihydrolipoyllysine-residue succinyltransferase) Oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA by alpha-ketoglutarate dehydrogenase
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [EntityWithAccessionedSequence:R-GGA-9853502] DLST [mitochondrial matrix]
precedingEvent	[Reaction:R-GGA-9853499] DLD dimer dehydrogenates dihydrolipoyl - Gallus gallus [Reaction:R-GGA-450984] IDH2 dimer decarboxylates isocitrate - Gallus gallus [Reaction:R-GGA-70979] MDH2 dimer dehydrogenates MAL - Gallus gallus [Reaction:R-GGA-450971] NNT dimer transfers proton from NADPH to NAD+ - Gallus gallus
regulatedBy	[PositiveRegulation:R-HSA-210348] Positive regulation by 'NADH [mitochondrial matrix]' [PositiveRegulation:9987148] Positive regulation by 'ATP [mitochondrial matrix]' [NegativeRegulation:9987149] Negative regulation by 'Ca2+ [mitochondrial matrix]' [NegativeRegulation:9987150] Negative regulation by 'ADP [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-71401
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-GGA-1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) [Reaction:R-GGA-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) [Reaction:R-GGA-1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria) [Reaction:R-GGA-1237047] CA4:Zn2+ hydrates CO2 to HCO3- [Reaction:R-GGA-1237069] RHAG transports CO2 from extracellular region to cytosol [Reaction:R-GGA-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol [Reaction:R-GGA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-GGA-9853512] DLST transfers succinyl to CoA [Reaction:R-GGA-71775] SUCLG1/G2 cleaves succinyl-CoA [Reaction:R-GGA-70997] SUCLG1/A2 cleaves succinyl-CoA
(hasEvent)	[Pathway:R-GGA-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG
(inferredTo)	[Reaction:R-HSA-71401] OGDH dimer decarboxylates 2-OG