2-Oxoglutarate dehydrogenase complex (OGDHC) component E1 (O...

created [InstanceEdit:9853770] Stephan, Ralf, 2023-11-21
dbId 9853750
displayName 2-Oxoglutarate dehydrogenase complex (OGDHC) component E1 (O...
schemaClass Summation
text 2-Oxoglutarate dehydrogenase complex (OGDHC) component E1 (OGDH) catalyzes the decarboxylation of alpha-oxoglutarate (?OG), at the same time transferring the resulting succinyl onto the lipoyl moiety of the E2 component (DLST) which gets reduced in the process. The enzyme is a homodimer, with each monomer binding one Ca2+ ion, one Mg2+ ion, and one thiamin molecule (PDB 7WGR; Zhong et al., 2022). OGDH activity is enhanced by ATP and NADH and decreased by Ca2+ and ADP. An alternative substrate of OGDH is 2-oxoadipate, which, in the end, leads to glutaryl-CoA, with a high amount of superoxide/ H2O2 produced as a side product (Armstrong et al., 2014; Nemeria et al., 2014; Nemeria et al., 2017).
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