Reactome | OGDH complex synthesizes succinyl-CoA from 2-OG

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OGDH complex synthesizes succinyl-CoA from 2-OG Show undefined attributes

authored	[InstanceEdit:9853489] Stephan, Ralf, 2023-11-05
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9853494] Stephan, Ralf, 2023-11-16
crossReference	[DatabaseIdentifier:9855643] RHEA:27787
dbId	9853506
displayName	OGDH complex synthesizes succinyl-CoA from 2-OG
edited	[InstanceEdit:9859599] Stephan, Ralf, 2024-01-22
eventOf	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle) - Homo sapiens
figure	[Figure:70727] /figures/oxidative_decarboxylation.jpg
goBiologicalProcess	[GO_BiologicalProcess:2455429] succinyl-CoA biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-71401] OGDH dimer decarboxylates 2-OG - Homo sapiens [Reaction:R-HSA-9853512] DLST transfers succinyl to CoA - Homo sapiens [Reaction:R-HSA-9853499] DLD dimer dehydrogenates dihydrolipoyl - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:69985] Subunit interactions in the mammalian alpha-ketoglutarate dehydrogenase complex. Evidence for direct association of the alpha-ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components [LiteratureReference:69983] Structure-function relationships in dihydrolipoamide acyltransferases [LiteratureReference:69972] The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes [LiteratureReference:9853682] Structural analysis of an endogenous 4-megadalton succinyl-CoA-generating metabolon [LiteratureReference:9853743] Structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate dehydrogenase complex (hKGDHc) revealed by cryo-EM and cross-linking mass spectrometry: Implications for the overall hKGDHc structure [LiteratureReference:9854476] MRPS36 provides a structural link in the eukaryotic 2-oxoglutarate dehydrogenase complex
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	OGDH complex synthesizes succinyl-CoA from 2-OG Succinyl-CoA Biosynthesis alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ Oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA by alpha-ketoglutarate dehydrogenase
orthologousEvent	[Pathway:R-DRE-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Danio rerio [Pathway:R-PFA-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Plasmodium falciparum [Pathway:R-SCE-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Saccharomyces cerevisiae [Pathway:R-SPO-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Schizosaccharomyces pombe [Pathway:R-DDI-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Dictyostelium discoideum [Pathway:R-CEL-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Caenorhabditis elegans [Pathway:R-DME-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Drosophila melanogaster [Pathway:R-GGA-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Gallus gallus [Pathway:R-XTR-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Xenopus tropicalis [Pathway:R-SSC-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Sus scrofa [Pathway:R-BTA-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Bos taurus [Pathway:R-CFA-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Canis familiaris [Pathway:R-RNO-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Rattus norvegicus [Pathway:R-MMU-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Mus musculus
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9853506
summation	[Summation:71402] The mitochondrial alpha-oxoglutarate dehydrogenase complex (...

Referrals

(hasEvent)

[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle)