Reactome | SUCLG1/G2 cleaves succinyl-CoA

Schema > Reaction > Entries

SUCLG1/G2 cleaves succinyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:71774] succinate-CoA ligase (GDP-forming) activity of SUCLG1:SUCLG2 [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643311] succinate-CoA ligase (GDP-forming) activity of SUCLG1:SUCLG2 [mitochondrial matrix] Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:12667623] RHEA:22122 [DatabaseIdentifier:9854182] RHEA:22122
dbId	71775
displayName	SUCLG1/G2 cleaves succinyl-CoA
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle) - Homo sapiens
followingEvent	[Reaction:R-HSA-163213] Transfer of electrons through the succinate dehydrogenase complex - Homo sapiens [Reaction:R-HSA-70994] SDH complex dehydrogenates succinate - Homo sapiens
input	[SimpleEntity:R-ALL-113525] GDP [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix] [SimpleEntity:R-ALL-70958] SUCC-CoA [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:156639] Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia [LiteratureReference:156645] Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes [LiteratureReference:156641] Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit. [LiteratureReference:156646] Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues [LiteratureReference:450989] Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion [LiteratureReference:156637] Guanosine triphosphate, the primary product of phosphorylation coupled to the breakdown of succinyl coenzyme A [LiteratureReference:9853989] SUCLG1 mutations and mitochondrial encephalomyopathy: a case study and review of the literature
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	SUCLG1/G2 cleaves succinyl-CoA GDP + phosphate + succinyl-CoA => CoA + GTP + succinate
negativePrecedingEvent	[NegativePrecedingEvent:9908914] Futile Cycle: DLST transfers succinyl to CoA
orthologousEvent	[Reaction:R-BTA-71775] SUCLG1/G2 cleaves succinyl-CoA - Bos taurus [Reaction:R-GGA-71775] SUCLG1/G2 cleaves succinyl-CoA - Gallus gallus [Reaction:R-DDI-71775] SUCLG1/G2 cleaves succinyl-CoA - Dictyostelium discoideum [Reaction:R-CEL-71775] SUCLG1/G2 cleaves succinyl-CoA - Caenorhabditis elegans [Reaction:R-DME-71775] SUCLG1/G2 cleaves succinyl-CoA - Drosophila melanogaster [Reaction:R-XTR-71775] SUCLG1/G2 cleaves succinyl-CoA - Xenopus tropicalis [Reaction:R-SSC-71775] SUCLG1/G2 cleaves succinyl-CoA - Sus scrofa [Reaction:R-CFA-71775] SUCLG1/G2 cleaves succinyl-CoA - Canis familiaris [Reaction:R-RNO-71775] SUCLG1/G2 cleaves succinyl-CoA - Rattus norvegicus [Reaction:R-MMU-71775] SUCLG1/G2 cleaves succinyl-CoA - Mus musculus
output	[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-113573] GTP [mitochondrial matrix] [SimpleEntity:R-ALL-113536] SUCCA [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-71401] OGDH dimer decarboxylates 2-OG - Homo sapiens [Reaction:R-HSA-71010] MUT isomerises L-MM-CoA to SUCC-CoA - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
revised	[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71775
summation	[Summation:9853992] Mitochondrial succinate CoA ligase (GDP-forming) catalyzes t...
updateTrackers	[UpdateTracker:9864164] Update Tracker - [Reaction:71775] SUCLG1/G2 cleaves succinyl-CoA - v88:[addLiteratureReference, add_removeSummation] [UpdateTracker:9791131] Update Tracker - [Reaction:71775] GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA - v32:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9864164] Update Tracker - [Reaction:71775] SUCLG1/G2 cleaves succinyl-CoA - v88:[addLiteratureReference, add_removeSummation] [UpdateTracker:9791131] Update Tracker - [Reaction:71775] GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA - v32:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle)
(precedingEvent)	[Reaction:R-HSA-163213] Transfer of electrons through the succinate dehydrogenase complex [Reaction:R-HSA-70994] SDH complex dehydrogenates succinate [NegativePrecedingEvent:9908915] Futile Cycle: SUCLG1/G2 cleaves succinyl-CoA

Cite Us!