Reactome | Carbonic anhydrase hydrates carbon dioxide (cytosol)

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Carbonic anhydrase hydrates carbon dioxide (cytosol) Show undefined attributes

authored	[InstanceEdit:1475033] May, B, 2011-08-06
catalystActivity	[CatalystActivity:1475014] carbonate dehydratase activity of CA1,2,3,7,13:Zinc [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1475019] May, B, 2011-08-07
crossReference	[DatabaseIdentifier:12668149] RHEA:10750
dbId	1475026
displayName	Carbonic anhydrase hydrates carbon dioxide (cytosol)
edited	[InstanceEdit:1475033] May, B, 2011-08-06
eventOf	[Pathway:R-HSA-1475029] Reversible hydration of carbon dioxide - Homo sapiens
input	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1237271] The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C [LiteratureReference:1237231] A 13C nuclear magnetic resonance study of CO2/HCO-3 exchange catalyzed by human carbonic anhydrase I [LiteratureReference:1237205] Buffer dependence of CO2 hydration catalyzed by human carbonic anhydrase I [LiteratureReference:1243058] Structure and mechanism of carbonic anhydrase [LiteratureReference:1237239] Anion inhibition of CO2 hydration catalyzed by human carbonic anhydrase II. Mechanistic implications [LiteratureReference:1237237] A chemical and enzymological comparison of the common major human erythrocyte carbonic anhydrase II, its minor component, and a new genetic variant, CA II Melbourne (237 Pro leads to His) [LiteratureReference:1237194] Proton magnetic resonance studies of carbonic anhydrase. II. Group controlling catalytic activity [LiteratureReference:1237250] Activation parameters for the carbonic anhydrase II-catalyzed hydration of CO2 [LiteratureReference:1237219] Characterization of human carbonic anhydrase III from skeletal muscle [LiteratureReference:1237242] Buffer enhancement of proton transfer in catalysis by human carbonic anhydrase III [LiteratureReference:1237196] Properties of intramolecular proton transfer in carbonic anhydrase III [LiteratureReference:1237267] Interactions of active-site residues and catalytic activity of human carbonic anhydrase III [LiteratureReference:1237259] Rate-equilibria relationships in intramolecular proton transfer in human carbonic anhydrase III [LiteratureReference:1237264] Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme [LiteratureReference:1237531] Identification of potent and selective human carbonic anhydrase VII (hCA VII) inhibitors [LiteratureReference:2186818] Structure and catalysis by carbonic anhydrase II: role of active-site tryptophan 5 [LiteratureReference:2186817] Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II [LiteratureReference:2186804] Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II [LiteratureReference:2186806] Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Carbonic anhydrase hydrates carbon dioxide (cytosol)
orthologousEvent	[Reaction:R-CEL-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Caenorhabditis elegans [Reaction:R-DME-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Drosophila melanogaster [Reaction:R-GGA-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Gallus gallus [Reaction:R-XTR-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Xenopus tropicalis [Reaction:R-DRE-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Danio rerio [Reaction:R-SSC-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Sus scrofa [Reaction:R-BTA-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Bos taurus [Reaction:R-CFA-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Canis familiaris [Reaction:R-RNO-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Rattus norvegicus [Reaction:R-MMU-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Mus musculus
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-111627] HCO3- [cytosol]
precedingEvent	[Reaction:R-HSA-70967] IDH3 complex decarboxylates isocitrate - Homo sapiens [Reaction:R-HSA-450984] IDH2 dimer decarboxylates isocitrate - Homo sapiens [Reaction:R-HSA-71401] OGDH dimer decarboxylates 2-OG - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2252565] Jassal, B, 2012-05-16 [InstanceEdit:2252567] Silverman, DN, 2012-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1475026
summation	[Summation:1475020] Carbonic anhydrase I (CA1, Khalifah 1971, Simonsson et al. 1...

Referrals

(reverseReaction)	[Reaction:R-HSA-1475022] Carbonic anhydrase dehydrates bicarbonate (cytosol)
(hasEvent)	[Pathway:R-HSA-1475029] Reversible hydration of carbon dioxide

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