Reactome | OGDH dimer decarboxylates 2-OG

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OGDH dimer decarboxylates 2-OG Show undefined attributes

catalystActivity	[CatalystActivity:10657385] oxoglutarate dehydrogenase (succinyl-transferring) activity of OGDH complex [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10657387
displayName	OGDH dimer decarboxylates 2-OG
eventOf	[Pathway:R-DME-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DME-9853512] DLST transfers succinyl to CoA - Drosophila melanogaster [Reaction:R-DME-70997] SUCLG1/A2 cleaves succinyl-CoA - Drosophila melanogaster [Reaction:R-DME-71775] SUCLG1/G2 cleaves succinyl-CoA - Drosophila melanogaster [Reaction:R-DME-1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) - Drosophila melanogaster [Reaction:R-DME-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Drosophila melanogaster [Reaction:R-DME-1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria) - Drosophila melanogaster [Reaction:R-DME-1237047] CA4:Zn2+ hydrates CO2 to HCO3- - Drosophila melanogaster [Reaction:R-DME-1237069] RHAG transports CO2 from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-DME-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-DME-163217] Complex I oxidises NADH to NAD+, reduces CoQ to QH2 - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-71401] OGDH dimer decarboxylates 2-OG - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [EntityWithAccessionedSequence:R-DME-69993] alpha-KGDHC [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
isInDisease	false
isInferred	true
name	OGDH dimer decarboxylates 2-OG 2-oxoglutarate + H(+) + N(6)-((R)-lipoyl)-L-lysyl-(dihydrolipoyllysine-residue succinyltransferase) => CO2 + N(6)-((R)-S(8)-succinyldihydrolipoyl)-L-lysyl-(dihydrolipoyllysine-residue succinyltransferase) Oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA by alpha-ketoglutarate dehydrogenase
output	[EntityWithAccessionedSequence:R-DME-9853502] alpha-KGDHC [mitochondrial matrix] [SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix]
precedingEvent	[Reaction:R-DME-70967] IDH3 complex decarboxylates isocitrate - Drosophila melanogaster
regulatedBy	[PositiveRegulation:R-HSA-210348] Positive regulation by 'NADH [mitochondrial matrix]' [PositiveRegulation:9866686] Positive regulation by 'ATP [mitochondrial matrix]' [NegativeRegulation:9866687] Negative regulation by 'Ca2+ [mitochondrial matrix]' [NegativeRegulation:9866688] Negative regulation by 'ADP [mitochondrial matrix]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-71401
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DME-1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) [Reaction:R-DME-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) [Reaction:R-DME-1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria) [Reaction:R-DME-1237047] CA4:Zn2+ hydrates CO2 to HCO3- [Reaction:R-DME-1237069] RHAG transports CO2 from extracellular region to cytosol [Reaction:R-DME-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol [Reaction:R-DME-9853512] DLST transfers succinyl to CoA [Reaction:R-DME-163217] Complex I oxidises NADH to NAD+, reduces CoQ to QH2 [Reaction:R-DME-70997] SUCLG1/A2 cleaves succinyl-CoA [Reaction:R-DME-71775] SUCLG1/G2 cleaves succinyl-CoA
(hasEvent)	[Pathway:R-DME-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG
(inferredTo)	[Reaction:R-HSA-71401] OGDH dimer decarboxylates 2-OG