Reactome | CHEK1 phosphorylates TP53

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CHEK1 phosphorylates TP53 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:182636] protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6799245] Orlic-Milacic, Marija, 2015-09-22
dbId	6799246
displayName	CHEK1 phosphorylates TP53
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation - Homo sapiens [Pathway:R-HSA-69473] G2/M DNA damage checkpoint - Homo sapiens
followingEvent	[Reaction:R-HSA-6805730] SETD9 methylates TP53 - Homo sapiens [Reaction:R-HSA-6805740] SETD8 methylates TP53 - Homo sapiens [Reaction:R-HSA-3222237] SMYD2 methylates TP53 - Homo sapiens [Reaction:R-HSA-6806417] TP53 binds the DDB2 gene - Homo sapiens [Reaction:R-HSA-6806413] TP53 binds the MLH1 gene - Homo sapiens [Reaction:R-HSA-6806408] TP53 binds the PMS2 gene - Homo sapiens [Reaction:R-HSA-6806412] TP53 and AP-1 bind the MSH2 promoter - Homo sapiens [Reaction:R-HSA-6806419] TP53 binds the FANCC gene - Homo sapiens [Reaction:R-HSA-6796649] TP53 binds the CCNK gene - Homo sapiens [Reaction:R-HSA-6804425] TP53 binds POU4F2 - Homo sapiens [Reaction:R-HSA-6799761] TP53 binds PPP1R13L - Homo sapiens [Reaction:R-HSA-6804402] TP53 binds POU4F1 - Homo sapiens [Reaction:R-HSA-3222093] BRD7 binds TP53 and EP300 - Homo sapiens [Reaction:R-HSA-6805620] KAT6A and PML bind TP53 - Homo sapiens [Reaction:R-HSA-6811479] ING2 recruits EP300 to TP53 - Homo sapiens [Reaction:R-HSA-6800042] TP53 binds the IGFBP3 gene - Homo sapiens [Reaction:R-HSA-5633414] TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes - Homo sapiens [Reaction:R-HSA-6791302] TP53 binds the AIFM2 gene promoter - Homo sapiens [Reaction:R-HSA-6797993] TP53 and CREBBP bind BNIP3L gene - Homo sapiens [Reaction:R-HSA-6801166] TP53 binds the STEAP3 gene - Homo sapiens [Reaction:R-HSA-6801209] TP53 binds the TRIAP1 gene - Homo sapiens [Reaction:R-HSA-6800253] TP53 binds the BCL6 gene - Homo sapiens [Reaction:R-HSA-6791327] TP53 binds the BCL2L14 gene - Homo sapiens [Reaction:R-HSA-5633295] TP53 binds the NDRG1 gene promoter - Homo sapiens [Reaction:R-HSA-6801087] TP53 binds the RABGGTA gene - Homo sapiens [Reaction:R-HSA-6800836] TP53 or TP63 binds the PERP gene - Homo sapiens [Reaction:R-HSA-6797766] TP53 binds the BIRC5 gene - Homo sapiens [Reaction:R-HSA-6800279] TP53 binds the PIDD1 gene - Homo sapiens [Reaction:R-HSA-6798129] TP53 binds the CASP6 gene - Homo sapiens [Reaction:R-HSA-6799418] TP53 binds the TP53INP1 gene - Homo sapiens [Reaction:R-HSA-6791387] TP53 binds the ARID3A gene - Homo sapiens [Reaction:R-HSA-6798304] TP53 binds the E2F7 gene - Homo sapiens [Reaction:R-HSA-3215152] TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter - Homo sapiens [Reaction:R-HSA-6803935] TP53 binds the PLAGL1 gene - Homo sapiens [Reaction:R-HSA-6804191] TP53 binds the PRDM1 gene - Homo sapiens [Reaction:R-HSA-6798282] TP53 and E2F4 bind the CDC25C gene - Homo sapiens [Reaction:R-HSA-6803425] TP53 binds ZNF385A gene - Homo sapiens [Reaction:R-HSA-6803391] TP53 binds the PCBP4 gene - Homo sapiens [Reaction:R-HSA-3786258] TP53 binds the CDKN1A promoter - Homo sapiens [Reaction:R-HSA-3700997] TP53 binds the MDM2 gene - Homo sapiens [Reaction:R-HSA-6801355] TP53 binds the NLRC4 gene - Homo sapiens [Reaction:R-HSA-6798138] TP53 binds the CASP10 gene - Homo sapiens [Reaction:R-HSA-9749464] TP53 binds the IKBIP gene promoter - Homo sapiens [Reaction:R-HSA-6799777] TP53 family members bind PPP1R13B or TP53BP2 - Homo sapiens [Reaction:R-HSA-6791285] TP53 binds the BID gene promoter - Homo sapiens [Reaction:R-HSA-6791349] TP53 binds the APAF1 gene promoter - Homo sapiens [Reaction:R-HSA-4331331] TP53 binds the PMAIP1 (NOXA) promoter - Homo sapiens [Reaction:R-HSA-9710323] TP53 or TP63 binds the GSDME gene - Homo sapiens [Reaction:R-HSA-3222128] NOC2L binds TP53 - Homo sapiens [Reaction:R-HSA-6798020] TP53 binds the BTG2 gene - Homo sapiens [Reaction:R-HSA-6801641] TP53 binds the PLK2 gene - Homo sapiens [Reaction:R-HSA-6802165] TP53 binds the PLK3 gene - Homo sapiens [Reaction:R-HSA-6803914] TP53 binds the RGCC gene - Homo sapiens [Reaction:R-HSA-6804242] TP53 binds the complex of JMY, EP300 and TTC5 - Homo sapiens [Reaction:R-HSA-3215251] TP53INP1 and HIPK2 bind TP53 - Homo sapiens [Reaction:R-HSA-6803719] TP53 binds ZNF385A - Homo sapiens [Reaction:R-HSA-6804441] RNF34 or RFFL ubiquitinates phosphorylated TP53 - Homo sapiens [Reaction:R-HSA-6805059] CK2:FACT phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-6798374] DYRK2 phosphorylates TP53 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-349474] p-S15-TP53 Tetramer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:69548] The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	CHEK1 phosphorylates TP53
orthologousEvent	[Reaction:R-MMU-6799246] CHEK1 phosphorylates TP53 - Mus musculus [Reaction:R-RNO-6799246] CHEK1 phosphorylates TP53 - Rattus norvegicus [Reaction:R-CFA-6799246] CHEK1 phosphorylates TP53 - Canis familiaris [Reaction:R-SSC-6799246] CHEK1 phosphorylates TP53 - Sus scrofa [Reaction:R-DME-6799246] CHEK1 phosphorylates TP53 - Drosophila melanogaster
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-3222171] p-S15,S20-TP53 Tetramer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6799332] ATR phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-5684887] Activation of CHEK1 at resected DNA DSBs - Homo sapiens [Reaction:R-HSA-264435] Dissociation of the COP1-p53 complex - Homo sapiens [Reaction:R-HSA-5693609] ATM phosphorylates TP53 at S15 - Homo sapiens [Reaction:R-HSA-176116] Recruitment and activation of Chk1 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6799246
summation	[Summation:6799250] CHEK1, activated by ATR-mediated phosphorylation, can phosph...

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