Reactome | TP53INP1 and HIPK2 bind TP53

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TP53INP1 and HIPK2 bind TP53 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3215248] Orlic-Milacic, M, 2013-03-15
dbId	3215251
displayName	TP53INP1 and HIPK2 bind TP53
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation - Homo sapiens
followingEvent	[Reaction:R-HSA-6799409] HIPK2 phosphorylates TP53 - Homo sapiens
input	[Complex:R-HSA-6799392] p-HIPK2:PIN1 [nucleoplasm] [Complex:R-HSA-3222171] p-S15,S20-TP53 Tetramer [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3215226] TP53INP1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3215228] TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity [LiteratureReference:3215254] p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis [LiteratureReference:6799386] HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation [LiteratureReference:6799393] HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop [LiteratureReference:6799379] Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	TP53INP1 and HIPK2 bind TP53
orthologousEvent	[Reaction:R-DRE-3215251] TP53INP1 and HIPK2 bind TP53 - Danio rerio [Reaction:R-DME-3215251] TP53INP1 and HIPK2 bind TP53 - Drosophila melanogaster [Reaction:R-SSC-3215251] TP53INP1 and HIPK2 bind TP53 - Sus scrofa [Reaction:R-BTA-3215251] TP53INP1 and HIPK2 bind TP53 - Bos taurus [Reaction:R-CFA-3215251] TP53INP1 and HIPK2 bind TP53 - Canis familiaris [Reaction:R-MMU-3215251] TP53INP1 and HIPK2 bind TP53 - Mus musculus
output	[Complex:R-HSA-3215242] TP53INP1:p-HIPK2:PIN1:p-S15,S20-TP53 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-6799416] TP53 stimulates expression of TP53INP1 - Homo sapiens [Reaction:R-HSA-6799246] CHEK1 phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-69685] CHEK2 phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-6805285] PLK3 phosphorylates TP53 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3215251
summation	[Summation:6799424] TP53INP1 (p53INP1) forms a complex with TP53 and its regulat...

Referrals

(hasEvent)	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation
(precedingEvent)	[Reaction:R-HSA-6799409] HIPK2 phosphorylates TP53