Reactome | TP53 family members bind PPP1R13B or TP53BP2

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TP53 family members bind PPP1R13B or TP53BP2 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6799774] Orlic-Milacic, Marija, 2015-09-25
dbId	6799777
displayName	TP53 family members bind PPP1R13B or TP53BP2
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804759] Regulation of TP53 Activity through Association with Co-factors - Homo sapiens
followingEvent	[Reaction:R-HSA-6799815] TP53 family members bind the FAS gene - Homo sapiens [Reaction:R-HSA-6799462] TP53 family members bind the TP53I3 (PIG3) gene promoter - Homo sapiens [Reaction:R-HSA-4331340] TP53 binds the BBC3 (PUMA) promoter - Homo sapiens [Reaction:R-HSA-3700981] TP53 family members bind the BAX promoter - Homo sapiens
input	[DefinedSet:R-HSA-6798076] p-S15,S20-TP53,TP63,TP73 [nucleoplasm] [DefinedSet:R-HSA-6799786] PPP1R13B,TP53BP2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6799790] Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax [LiteratureReference:6799748] Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73 [LiteratureReference:6799772] ASPP proteins specifically stimulate the apoptotic function of p53 [LiteratureReference:6799791] ASPP1 and ASPP2: common activators of p53 family members
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	TP53 family members bind PPP1R13B or TP53BP2 p53 family members bind ASPP1 or ASPP2
orthologousEvent	[Reaction:R-DME-6799777] TP53 family members bind PPP1R13B or TP53BP2 - Drosophila melanogaster [Reaction:R-GGA-6799777] TP53 family members bind PPP1R13B or TP53BP2 - Gallus gallus [Reaction:R-XTR-6799777] TP53 family members bind PPP1R13B or TP53BP2 - Xenopus tropicalis [Reaction:R-DRE-6799777] TP53 family members bind PPP1R13B or TP53BP2 - Danio rerio [Reaction:R-SSC-6799777] TP53 family members bind PPP1R13B or TP53BP2 - Sus scrofa [Reaction:R-BTA-6799777] TP53 family members bind PPP1R13B or TP53BP2 - Bos taurus [Reaction:R-CFA-6799777] TP53 family members bind PPP1R13B or TP53BP2 - Canis familiaris [Reaction:R-RNO-6799777] TP53 family members bind PPP1R13B or TP53BP2 - Rattus norvegicus [Reaction:R-MMU-6799777] TP53 family members bind PPP1R13B or TP53BP2 - Mus musculus
output	[Complex:R-HSA-6799788] (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6799246] CHEK1 phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-69685] CHEK2 phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-6805285] PLK3 phosphorylates TP53 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6799777
summation	[Summation:6799781] TP53 (p53) forms a complex with PPP1R13B (ASPP1) or TP53BP2 ...

Referrals

(hasEvent)	[Pathway:R-HSA-6804759] Regulation of TP53 Activity through Association with Co-factors
(precedingEvent)	[Reaction:R-HSA-6799815] TP53 family members bind the FAS gene [Reaction:R-HSA-6799462] TP53 family members bind the TP53I3 (PIG3) gene promoter [Reaction:R-HSA-4331340] TP53 binds the BBC3 (PUMA) promoter [Reaction:R-HSA-3700981] TP53 family members bind the BAX promoter

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