Reactome | G2/M DNA damage checkpoint

Schema > Pathway > Entries

G2/M DNA damage checkpoint Show undefined attributes

created	[InstanceEdit:68869] Walworth, N, O'Donnell, M, 2003-06-05
crossReference	[DatabaseIdentifier:12325450] BioModels Database:BIOMD0000000939
dbId	69473
displayName	G2/M DNA damage checkpoint
eventOf	[Pathway:R-HSA-69481] G2/M Checkpoints - Homo sapiens
figure	[Figure:9689490] /figures/static/R-HSA-69473.svg
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-176116] Recruitment and activation of Chk1 - Homo sapiens [Reaction:R-HSA-5683735] CHEK2 is recruited to DNA DSBs - Homo sapiens [Reaction:R-HSA-69891] Phosphorylation and activation of CHEK2 by ATM - Homo sapiens [Reaction:R-HSA-5683774] p-T68-CHEK2 dimerizes - Homo sapiens [Reaction:R-HSA-5683792] p-T68-CHEK2 autophosphorylates - Homo sapiens [Pathway:R-HSA-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Homo sapiens [Reaction:R-HSA-6799332] ATR phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-6799246] CHEK1 phosphorylates TP53 - Homo sapiens
isInDisease	false
isInferred	false
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	G2/M DNA damage checkpoint
orthologousEvent	[Pathway:R-PFA-69473] G2/M DNA damage checkpoint - Plasmodium falciparum [Pathway:R-SCE-69473] G2/M DNA damage checkpoint - Saccharomyces cerevisiae [Pathway:R-SPO-69473] G2/M DNA damage checkpoint - Schizosaccharomyces pombe [Pathway:R-DDI-69473] G2/M DNA damage checkpoint - Dictyostelium discoideum [Pathway:R-CEL-69473] G2/M DNA damage checkpoint - Caenorhabditis elegans [Pathway:R-DME-69473] G2/M DNA damage checkpoint - Drosophila melanogaster [Pathway:R-GGA-69473] G2/M DNA damage checkpoint - Gallus gallus [Pathway:R-XTR-69473] G2/M DNA damage checkpoint - Xenopus tropicalis [Pathway:R-DRE-69473] G2/M DNA damage checkpoint - Danio rerio [Pathway:R-SSC-69473] G2/M DNA damage checkpoint - Sus scrofa [Pathway:R-BTA-69473] G2/M DNA damage checkpoint - Bos taurus [Pathway:R-CFA-69473] G2/M DNA damage checkpoint - Canis familiaris [Pathway:R-RNO-69473] G2/M DNA damage checkpoint - Rattus norvegicus [Pathway:R-MMU-69473] G2/M DNA damage checkpoint - Mus musculus
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-69473
summation	[Summation:69475] Throughout the cell cycle, the genome is constantly monitore...

Referrals

(hasEvent)

[Pathway:R-HSA-69481] G2/M Checkpoints

Cite Us!