Reactome | CK2:FACT phosphorylates TP53

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CK2:FACT phosphorylates TP53 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:6805058] protein serine/threonine kinase activity of CK2:FACT [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6805049] Orlic-Milacic, Marija, 2015-10-16
dbId	6805059
displayName	CK2:FACT phosphorylates TP53
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-3222171] p-S15,S20-TP53 Tetramer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6805051] A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1 [LiteratureReference:6805050] p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	CK2:FACT phosphorylates TP53
orthologousEvent	[Reaction:R-XTR-6805059] CK2:FACT phosphorylates TP53 - Xenopus tropicalis [Reaction:R-DME-6805059] CK2:FACT phosphorylates TP53 - Drosophila melanogaster [Reaction:R-DRE-6805059] CK2:FACT phosphorylates TP53 - Danio rerio [Reaction:R-SSC-6805059] CK2:FACT phosphorylates TP53 - Sus scrofa [Reaction:R-BTA-6805059] CK2:FACT phosphorylates TP53 - Bos taurus [Reaction:R-CFA-6805059] CK2:FACT phosphorylates TP53 - Canis familiaris [Reaction:R-RNO-6805059] CK2:FACT phosphorylates TP53 - Rattus norvegicus [Reaction:R-MMU-6805059] CK2:FACT phosphorylates TP53 - Mus musculus
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-6805046] p-S15,S20,S392-TP53 Tetramer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6805061] CK2 binds FACT - Homo sapiens [Reaction:R-HSA-6799246] CHEK1 phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-69685] CHEK2 phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-6805285] PLK3 phosphorylates TP53 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6805059
summation	[Summation:6805069] Casein kinase II (CK2), associated with the FACT2 complex, p...

Referrals

(hasEvent)

[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation